Palladium-Catalyzed Reaction of Arylboronic Acids with Aliphatic Nitriles: Synthesis of Alkyl Aryl Ketones and 2-Arylbenzofurans

被引：29

作者：

Wang, Xingyong ^{[1
]}

Wang, Xiaodong ^{[1
]}

Liu, Miaochang ^{[1
]}

Ding, Jinchang ^{[1
,2
]}

Chen, Jiuxi ^{[1
]}

Wu, Huayue ^{[1
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 3250235, Peoples R China

[2] Wenzhou Vocat & Tech Coll, Wenzhou 325035, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2013年 / 45卷 / 16期

基金：

中国国家自然科学基金;

关键词：

palladium; aliphatic nitriles; arylboronic acids; alkyl aryl ketones; 2-arylbenzofurans; CROSS-COUPLING REACTIONS; PALLADIUM(II)-CATALYZED ADDITION; ALPHA-ARYLATION; DERIVATIVES; ALDEHYDES; ARENES; ACTIVATION; COMPLEXES;

D O I：

10.1055/s-0033-1338909

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient palladium-catalyzed addition of arylboronic acids to aliphatic nitriles has been developed, providing a wide range of alkyl aryl ketones in moderate to excellent yields. It is noteworthy that sequential addition and intramolecular annulation reaction of 2-(2-hydroxyphenyl)acetonitriles with arylboronic acids are also conducted smoothly to afford 2-arylbenzofurans in good yields under the standard conditions.

引用

页码：2241 / 2244

页数：4

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