Therapeutic Potential of Nitric Oxide Donors in Cancer: Focus on Angiogenesis

被引：4
|
作者：
Morbidelli, Lucia [1 ]
机构：
[1] Univ Siena, Dept Life Sci, Lab Pharmacol Angiogenesis & Microcirculat, Via A Moro 2, I-53100 Siena, Italy
来源：
CRITICAL REVIEWS IN ONCOGENESIS | 2016年 / 21卷 / 5-6期
关键词：
Angiogenesis; Apoptosis; NO donors; NO hybrids; Tumor growth;
D O I：
10.1615/CritRevOncog.2017021114
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new challenge to overcoming tumor resistance to conventional treatment is represented by the development of novel nitric oxide (NO) donors. It is now clear that while low doses of NO have proneoplastic properties, high doses exert antitumor/antiangiogenic activities through multiple mechanisms. This review focuses on the role of exogenous NO in cancer therapy and reports the state of the art regarding different NO-donating agents in cancer treatment, particularly in relation to angiogenesis inhibition.
引用
收藏
页码：447 / 458
页数：12
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