Natural Killer T cell obsession with self-antigens

被引：77

作者：

Gapin, Laurent ^{[1
,2
]}

Godfrey, Dale I. ^{[3
]}

Rossjohn, Jamie ^{[4
]}

机构：

[1] Univ Colorado, Dept Immunol, Denver Sch Med, Denver, CO 80206 USA

[2] Natl Jewish Hlth, Denver, CO 80206 USA

[3] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia

[4] Monash Univ, Dept Biochem & Mol Biol, Sch Biomed Sci, Clayton, Vic 3800, Australia

来源：

CURRENT OPINION IN IMMUNOLOGY | 2013年 / 25卷 / 02期

基金：

澳大利亚研究理事会; 美国国家卫生研究院; 澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

INVARIANT NKT CELLS; HUMAN CD1D MOLECULES; ADIPOSE-TISSUE; MICROBIAL INFECTION; CYTOKINE PRODUCTION; INSULIN-RESISTANCE; DENDRITIC CELLS; INKT CELLS; RECOGNITION; ACTIVATION;

D O I：

10.1016/j.coi.2013.01.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural Killer T (NKT) cells are distinct lymphocyte lineages that recognize lipid antigens presented by the non-classical Major Histocompatibility Complex molecule CD1d. Two categories of NKT cells, type I and type II, have been described based on T-cell receptor expression and antigenic specificity. In both cases, increasing evidence suggest that recognition of self-antigens by these cells plays an important role not only in their development but also in their regulation of a broad range of immune responses. Here we review recent advances in our understanding of how and when NKT cell autoreactivity manifests itself, how the NKT T cell receptor engages self-antigens and the nature of these self-antigens.

引用

页码：168 / 173

页数：6

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