Photonic crystal surface mode imaging for multiplexed and high-throughput label-free biosensing

被引：15
作者：
Konopsky, Valery [1 ]
Mitko, Tatiana [2 ]
Aldarov, Konstantin [2 ]
Alieva, Elena [1 ]
Basmanov, Dmitry [2 ]
Moskalets, Aleksandr [2 ]
Matveeva, Ainur [2 ]
Morozova, Olga [2 ]
Klinov, Dmitry [2 ]
机构：
[1] Inst Spect, Fizicheskaya 5, Troitsk 108840, Russia
[2] Fed Med Biol Agcy, Fed Res & Clin Ctr Phys Chem Med, Pirogovskaya 1a, Moscow 119435, Russia
来源：
BIOSENSORS & BIOELECTRONICS | 2020年 / 168卷
基金：
俄罗斯科学基金会; 俄罗斯基础研究基金会;
关键词：
Label-free optical biosensors; Surface wave imaging; Photonic crystal surface modes; SPRi; PCSMi; PLASMON RESONANCE; WAVES;
D O I：
10.1016/j.bios.2020.112575
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
A photonic crystal surface mode imaging (PCSMi) technique is implemented for the simultaneous detection of antibody binding with specific antigens in arrays containing 96- and 384-spots. Like the surface plasmon resonance imaging (SPRi) technique, the presented approach is label-free and permits interrogating an analyte by hundreds of different ligands immobilized in small spots. The adsorption kinetics is recorded with a subpicogram resolution at every spot simultaneously. Possible implementations of this technique for multiplexed and high-throughput biosensing are discussed.
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页数：5
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