β-Lactams as promising anticancer agents: Molecular hybrids, structure activity relationships and potential targets

被引：38

作者：

Fu, Dong-Jun ^{[1
]}

Zhang, Yun-Feng ^{[1
]}

Chang, An-Qi ^{[1
]}

Li, Jun ^{[1
]}

机构：

[1] Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Sch Chinese Mat Med, Beijing 100029, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2020年 / 201卷

关键词：

beta-Lactam; Molecular hybridization approach; Structure activity relationship; Anticancer mechanisms; NF-KAPPA-B; ANAPLASTIC LYMPHOMA KINASE; C-H INSERTION; BIOLOGICAL EVALUATION; STEREOSELECTIVE-SYNTHESIS; BREAST-CANCER; PROTEASOME INHIBITOR; REFORMATSKY REACTION; ANTITUMOR-ACTIVITY; BUILDING-BLOCKS;

D O I：

10.1016/j.ejmech.2020.112510

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

beta-Lactam, commonly referred as azetidin-2-one, is a multifunctional building block for synthesizing beta-amino ketones, gamma-amino alcohols, and other compounds. Besides its well known antibiotic activity, this ring system exhibits a wide range of activities, attracting the attention of researchers. However, the structurally diverse beta-lactam analogues as anticancer agents and their different molecular targets are poorly discussed. The purpose of this review is 3-fold: (1) to explore the molecular hybridization approach to design beta-lactams hybrids as anticancer agents; (2) the structure activity relationship of the most active anticancer beta-lactams and (3) to summarize their antitumor mechanisms. (C) 2020 Elsevier Masson SAS. All rights reserved.

引用

页数：21

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