Inwardly rectifying K+ channels 4.1 and 5.1 (Kir4.1/Kir5.1) in the renal distal nephron

被引：18

作者：

Wang, Wen-Hui ^{[1
]}

Lin, Dao-Hong ^{[1
]}

机构：

[1] New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | 2022年 / 323卷 / 02期

基金：

美国国家卫生研究院;

关键词：

East syndrome; Kcnj10; Kcnj16; K+ excretion; Na-Cl cotransporter; SeSAME syndrome; SODIUM-CHLORIDE COTRANSPORTER; CORTICAL COLLECTING DUCT; NA-CL COTRANSPORTER; KELCH-LIKE; POTASSIUM CHANNEL; CONVOLUTED TUBULE; BASOLATERAL MEMBRANE; SENSORINEURAL DEAFNESS; DIETARY K+; IN-VIVO;

D O I：

10.1152/ajpcell.00096.2022

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The inwardly rectifying potassium channel (Kir) 4.1 (encoded by KCNJ10) interacts with Kir5.1 (encoded by KCNJ16) to form a major basolateral K+ channel in the renal distal convoluted tubule (DCT), connecting tubule (CNT), and the cortical collecting duct (CCD). Kir4.1/Kir5.1 heterotetramer plays an important role in regulating Na+ and K+ transport in the DCT, CNT, and CCD. A recent development in the field has firmly established the role of Kir4.1/Kir5.1 heterotetramer of the DCT in the regulation of thiazide-sensitive Na-Cl cotransporter (NCC). Changes in Kir4.1/Kir5.1 activity of the DCT are an essential step for the regulation of NCC expression/activity induced by dietary K+ and Na+ intakes and play a role in modulating NCC by type 2 angiotensin II receptor (AT2R), bradykinin type II receptor (BK2R), and beta-adrenergic receptor. Since NCC activity determines the Na+ delivery rate to the aldosterone-sensitive distal nephron (ASDN), a distal nephron segment from late DCT to CCD, Kir4.1/Kir5.1 activity plays a critical role not only in the regulation of renal Na+ absorption but also in modulating renal K+ excretion and maintaining K+ homeostasis. Thus, Kir4.1/Kir5.1 activity serves as an important component of renal K+ sensing mechanism. The main focus of this review is to provide an overview regarding the role of Kir4.1 and Kir5.1 of the DCT and CCD in the regulation of renal K+ excretion and Na+ absorption.

引用

页码：C277 / C288

页数：12

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