A novel Ag/AgO/carboxymethyl chitosan bacteriostatic hydrogel for drug delivery

被引：12
作者：
Xu, Yanqin [1 ]
Liu, Jie [1 ]
Guan, Shumin [1 ]
Dong, Aotong [2 ,3 ]
Cao, Yuan [1 ]
Chen, Changguo [1 ]
机构：
[1] Chongqing Univ, Sch Chem & Chem Engn, Chongqing 401331, Peoples R China
[2] Chongqing Univ, Sch Journalism & Commun, Chongqing 401331, Peoples R China
[3] Chongqing Univ, Sch Big Data & Software Engn, Chongqing 401331, Peoples R China
来源：
MATERIALS RESEARCH EXPRESS | 2020年 / 7卷 / 08期
关键词：
silver; silver oxide; carboxymethyl chitosan; pH-sensitive hydrogel; antibacterial property; ORTHO ESTER LINKAGE; CARBOXYMETHYL CHITOSAN; SMART HYDROGEL; IN-VITRO; DEGRADATION; NANOPARTICLES; MICROSPHERES;
D O I：
10.1088/2053-1591/aba5cd
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
pH-sensitive Ag/AgO/carboxymethyl chitosan (CMCS) bacteriostatic hydrogels and Ag/AgO/CMCS/Aspirin (ASP) carrier hydrogels were prepared by Ag/AgOin situprecipitation method, and the effects of swelling, degradation, drug release and antibacterial properties of hydrogels were studied. The network of Ag/AgO/CMCS/ASP drug-loaded gels produced was mainly cross-linking by hydrogen bonding and intermolecular forces, and the cross-linking silver was mainly present in the elemental Ag and Ag(2+)states. Under the condition of buffer solution pH = 7.4, the cumulative release amount of Ag/AgO/CMCS/ASP drug-loaded gel was 75.20% within 12 h, and the inhibition rate of Gram-negativeEscherichia coli(E. coli) reached the maximum of 92.32%, which had broad application prospects in the medical field.
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页数：12
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