Chiral switches of chloroquine and hydroxychloroquine: potential drugs to treat COVID-19

被引:27
作者
D'Acquarica, Ilaria [1 ]
Agranat, Israel [2 ]
机构
[1] Sapienza Univ Roma, Dipartimento Chim & Tecnol Farm, Rome, Italy
[2] Hebrew Univ Jerusalem, Inst Chem, Organ Chem, Edmond J Safra Campus, IL-9190401 Jerusalem, Israel
关键词
D O I
10.1016/j.drudis.2020.04.021
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
[No abstract available]
引用
收藏
页码:1121 / 1123
页数:3
相关论文
共 10 条
[1]   The predicated demise of racemic new molecular entities is an exaggeration [J].
Agranat, Israel ;
Wainschtein, Silvya R. ;
Zusman, Enav Z. .
NATURE REVIEWS DRUG DISCOVERY, 2012, 11 (12) :972-973
[2]   The market of chiral drugs: Chiral switches versus de novo enantiomerically pure compounds [J].
Calcaterra, Andrea ;
D'Acquarica, Ilaria .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2018, 147 :323-340
[3]   Chloroquine and hydroxychloroquine as available weapons to fight COVID-19 [J].
Colson, Philippe ;
Rolain, Jean-Marc ;
Lagier, Jean-Christophe ;
Brouqui, Philippe ;
Raoult, Didier .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2020, 55 (04)
[4]   Chloroquine for the 2019 novel coronavirus SARS-CoV-2 [J].
Colson, Philippe ;
Rolain, Jean-Marc ;
Raoult, Didier .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2020, 55 (03)
[5]   ENANTIOSELECTIVE DISPOSITION OF HYDROXYCHLOROQUINE AFTER A SINGLE ORAL DOSE OF THE RACEMATE TO HEALTHY-SUBJECTS [J].
DUCHARME, J ;
FIEGER, H ;
DUCHARME, MP ;
KHALIL, SKW ;
WAINER, IW .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1995, 40 (02) :127-133
[6]   Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies [J].
Gao, Jianjun ;
Tian, Zhenxue ;
Yang, Xu .
BIOSCIENCE TRENDS, 2020, 14 (01) :72-73
[7]   Urgent Guidance for Navigating and Circumventing the QTc-Prolonging and Torsadogenic Potential of Possible Pharmacotherapies for Coronavirus Disease 19 (COVID-19) [J].
Giudicessi, John R. ;
Noseworthy, Peter A. ;
Friedman, Paul A. ;
Ackerman, Michael J. .
MAYO CLINIC PROCEEDINGS, 2020, 95 (06) :1213-1221
[8]   Therapeutic options for the 2019 novel coronavirus (2019-nCoV) [J].
Li, Guangdi ;
De Clercq, Erik .
NATURE REVIEWS DRUG DISCOVERY, 2020, 19 (03) :149-150
[9]   Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro [J].
Liu, Jia ;
Cao, Ruiyuan ;
Xu, Mingyue ;
Wang, Xi ;
Zhang, Huanyu ;
Hu, Hengrui ;
Li, Yufeng ;
Hu, Zhihong ;
Zhong, Wu ;
Wang, Manli .
CELL DISCOVERY, 2020, 6 (01)
[10]   Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro [J].
Wang, Manli ;
Cao, Ruiyuan ;
Zhang, Leike ;
Yang, Xinglou ;
Liu, Jia ;
Xu, Mingyue ;
Shi, Zhengli ;
Hu, Zhihong ;
Zhong, Wu ;
Xiao, Gengfu .
CELL RESEARCH, 2020, 30 (03) :269-271