Genetic mechanisms of virulence in Listeria monocytogenes

被引：1

作者：

Ermolaeva, SA ^{[1
]}

机构：

[1] Russian Acad Med Sci, NF Gamaleya Epidemiol & Microbiol Res Inst, Moscow 123098, Russia

来源：

RUSSIAN JOURNAL OF GENETICS | 2001年 / 37卷 / 03期

关键词：

D O I：

10.1023/A:1009044707398

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Current data on genetic determinants of virulence in Listeria monocytogenes and on factors affecting their expression are reviewed. The role of the PrfA protein, the only known transcriptional regulator that directly affects virulence gene expression and mechanisms responsible for the activity and/or concentration of this protein in the cell are considered. Detailed information of external signals modulating the level of virulence factor expression is provided. Data that favor the involvement of autoregulatory processes in the expression of virulence genes are considered, and a model of regulation to explain these data is proposed.

引用

页码：213 / 219

页数：7

共 46 条

[1] Spatial control of actin filament assembly:: Lessons from Listeria [J].

Beckerle, MC .

CELL, 1998, 95 (06) :741-748

[2]

Behari J, 1998, J BACTERIOL, V180, P6316

[3] Specific binding of the Listeria monocytogenes transcriptional regulator PrfA to target sequences requires additional factor(s) and is influenced by iron [J].

Bockmann, R ;

Dickneite, C ;

Middendorf, B ;

Goebel, W ;

Sokolovic, Z .

MOLECULAR MICROBIOLOGY, 1996, 22 (04) :643-653

[4] TRANSCRIPTIONAL REGULATION OF PRFA AND PRFA-REGULATED VIRULENCE GENES IN LISTERIA-MONOCYTOGENES [J].

BOHNE, J ;

SOKOLOVIC, Z ;

GOEBEL, W .

MOLECULAR MICROBIOLOGY, 1994, 11 (06) :1141-1150

[5] The bvr locus of Listeria monocytogenes mediates virulence gene repression by β-glucosides [J].

Brehm, K ;

Ripio, MT ;

Kreft, J ;

Vázquez-Boland, JA .

JOURNAL OF BACTERIOLOGY, 1999, 181 (16) :5024-5032

[6]

Bubert A, 1999, MOL GEN GENET, V261, P323, DOI 10.1007/s004380050973

[7] Cellular microbiology emerging [J].

Cossart, P ;

Boquet, P ;

Normark, S ;

Rappuoli, R .

SCIENCE, 1996, 271 (5247) :315-316

[8] Interactions of Listeria monocytogenes with mammalian cells during entry and actin-based movement:: bacterial factors, cellular ligands and signaling [J].

Cossart, P ;

Lecuit, M .

EMBO JOURNAL, 1998, 17 (14) :3797-3806

[9] DETECTION OF A PRFA-INDEPENDENT PROMOTER RESPONSIBLE FOR LISTERIOLYSIN GENE-EXPRESSION IN MUTANT LISTERIA-MONOCYTOGENES STRAINS LACKING THE PRFA REGULATOR [J].

DOMANN, E ;

WEHLAND, J ;

NIEBUHR, K ;

HAFFNER, C ;

LEIMEISTERWACHTER, M ;

CHAKRABORTY, T .

INFECTION AND IMMUNITY, 1993, 61 (07) :3073-3075

[10]

Ermolaeva S, 1997, FEMS MICROBIOL LETT, V150, P189, DOI 10.1016/S0378-1097(97)00110-9

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