Acute irritant threshold correlates with barrier function, skin hydration and contact hypersensitivity in atopic dermatitis and rosacea

被引：73

作者：

Darlenski, Razvigor ^{[1
]}

Kazandjieva, Jana ^{[2
]}

Tsankov, Nikolai ^{[1
]}

Fluhr, Joachim W. ^{[3
]}

机构：

[1] Tokuda Hosp, Dept Dermatol & Venereol, Sofia 1407, Bulgaria

[2] Med Univ, Fac Med, Dept Dermatol & Venereol, Sofia, Bulgaria

[3] Charite, Dept Dermatol, D-13353 Berlin, Germany

来源：

EXPERIMENTAL DERMATOLOGY | 2013年 / 22卷 / 11期

关键词：

barrier function; contact sensitization; irritant threshold; stratum corneum hydration; transepidermal water loss; FILAGGRIN GENE; SUSCEPTIBILITY; SENSITIZATION;

D O I：

10.1111/exd.12251

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The aim of the study was to disclose interactions between epidermal barrier, skin irritation and sensitization in healthy and diseased skin. Transepidermal water loss (TEWL) and stratum corneum hydration (SCH) were assessed in adult patients with atopic dermatitis (AD), rosacea and healthy controls. A 4-h patch test with seven concentrations of sodium lauryl sulphate was performed to determine the irritant threshold (IT). Contact sensitization pattern was revealed by patch testing with European baseline series. Subjects with a lower IT had higher TEWL values and lower SCH. Subjects with positive allergic reactions had significantly lower IT. In AD, epidermal barrier deterioration was detected on both volar forearm and nasolabial fold, while in rosacea, impeded skin physiology parameters were observed on the facial skin only, suggesting that barrier impediment is restricted to the face in rosacea, in contrast with AD where the abnormal skin physiology is generalized.

引用

页码：752 / 753

页数：2

共 12 条

[1]

AGNER T, 1991, ACTA DERM-VENEREOL, V71, P296

[2] Loss-of-function polymorphisms in the filaggrin gene are associated with an increased susceptibility to chronic irritant contact dermatitis: a case-control study [J].

de Jongh, C. M. ;

Khrenova, L. ;

Verberk, M. M. ;

Calkoen, F. ;

van Dijk, F. J. H. ;

Voss, H. ;

John, S. M. ;

Kezic, S. .

BRITISH JOURNAL OF DERMATOLOGY, 2008, 159 (03) :621-627

[3] Skin irritation and sensitization: Mechanisms and new approaches for risk assessment [J].

Fluhr, J. W. ;

Darlenski, R. ;

Angelova-Fischer, I. ;

Tsankov, N. ;

Basketter, D. .

SKIN PHARMACOLOGY AND PHYSIOLOGY, 2008, 21 (03) :124-135

[4]

Fregert S., 1981, MANUAL CONTACT DERMA

[5] Contact allergy, irritancy and 'danger' [J].

McFadden, JP ;

Basketter, DA .

CONTACT DERMATITIS, 2000, 42 (03) :123-127

[6] Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis [J].

Palmer, CNA ;

Irvine, AD ;

Terron-Kwiatkowski, A ;

Zhao, YW ;

Liao, HH ;

Lee, SP ;

Goudie, DR ;

Sandilands, A ;

Campbell, LE ;

Smith, FJD ;

O'Regan, GM ;

Watson, RM ;

Cecil, JE ;

Bale, SJ ;

Compton, JG ;

DiGiovanna, JJ ;

Fleckman, P ;

Lewis-Jones, S ;

Arseculeratne, G ;

Sergeant, A ;

Munro, CS ;

El Houate, B ;

McElreavey, K ;

Halkjaer, LB ;

Bisgaard, H ;

Mukhopadhyay, S ;

McLean, WHI .

NATURE GENETICS, 2006, 38 (04) :441-446

[7]

Seidenari S, 1995, ACTA DERM-VENEREOL, V75, P429

[8] Irritant dermatitis, irritancy and its role in allergic contact dermatitis [J].

Smith, HR ;

Basketter, DA ;

McFadden, JP .

CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2002, 27 (02) :138-146

[9] The association between null mutations in the filaggrin gene and contact sensitization to nickel and other chemicals in the general population [J].

Thyssen, J. P. ;

Johansen, J. D. ;

Linneberg, A. ;

Menne, T. ;

Nielsen, N. H. ;

Meldgaard, M. ;

Szecsi, P. B. ;

Stender, S. ;

Carlsen, B. C. .

BRITISH JOURNAL OF DERMATOLOGY, 2010, 162 (06) :1278-1285

[10] SUSCEPTIBILITY TO IRRITANTS - ROLE OF BARRIER FUNCTION, SKIN DRYNESS AND HISTORY OF ATOPIC-DERMATITIS [J].

TUPKER, RA ;

PINNAGODA, J ;

COENRAADS, PJ ;

NATER, JP .

BRITISH JOURNAL OF DERMATOLOGY, 1990, 123 (02) :199-205

← 1 2 →