Effect of trimethoprim-sulfamethoxazole prophylaxis in AIDS patients on the formation of the small colony variant phenotype of Staphylococcus aureus

被引:14
|
作者
von Eiff, C [1 ]
Lubritz, G
Heese, C
Peters, G
Becker, K
机构
[1] Univ Munster, Inst Med Microbiol, Hosp & Clin, Munster, Germany
[2] Univ Munster, Dept Internal Med B, Hosp & Clin, Munster, Germany
关键词
Staphylococcus aureus; small colony variants; SCVs; AIDs; prophylaxis;
D O I
10.1016/j.diagmicrobio.2003.10.010
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Emergence of Staphylococcus aureus small colony variants (SCVs) has been associated with antibiotic use, particularly with trimethoprim-sulfamethoxazole (TMP-SMZ). In this study, 634 specimens of 125 patients with AIDS were prospectively screened for S. aureus with normal phenotype and for S. aureus SCVs. Charts of these patients were reviewed for previous prophylaxis with TMP-SMZ often used as long-term pneumocystosis prophylaxis. Thirty-seven patients (29.6%) harbored S. aureus in their anterior nares, three of these patients (8.1%) had S. aureus SCVs. Interestingly, TMP-SMZ does not appear to select for S. aureus SCVs in nasal swabs of these patients. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:191 / 194
页数:4
相关论文
共 50 条
  • [21] Effect of long-term trimethoprim-sulfamethoxazole prophylaxis on ascites formation, bacterial translocation, spontaneous bacterial peritonitis, and survival in cirrhotic rats
    Guarner, C
    Runyon, BA
    Heck, M
    Young, S
    Sheikh, MY
    DIGESTIVE DISEASES AND SCIENCES, 1999, 44 (10) : 1957 - 1962
  • [22] Effect of Long-Term Trimethoprim-Sulfamethoxazole Prophylaxis on Ascites Formation, Bacterial Translocation, Spontaneous Bacterial Peritonitis, and Survival in Cirrhotic Rats
    Carlos Guarner
    Bruce A. Runyon
    Mary Heck
    Sharon Young
    Muhammad Y. Sheikh
    Digestive Diseases and Sciences, 1999, 44 : 1957 - 1962
  • [23] TRIMETHOPRIM-SULFAMETHOXAZOLE OR CLINDAMYCIN FOR TREATMENT OF COMMUNITY-ACQUIRED METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS SKIN AND SOFT TISSUE INFECTIONS
    Hyun, David Y.
    Mason, Edward O.
    Forbes, Andrea
    Kaplan, Sheldon L.
    PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2009, 28 (01) : 57 - 59
  • [24] Staphylococcus aureus small-colony variants: Formation, infection, and treatment
    Zhou, Shengzhe
    Rao, Yifan
    Li, Jia
    Huang, Qiaoyi
    Rao, Xiancai
    MICROBIOLOGICAL RESEARCH, 2022, 260
  • [25] Effect of Prophylactic Dose of Trimethoprim-Sulfamethoxazole on Serum Creatinine in Japanese Patients With Connective Tissue Diseases
    Kawato, Rui
    Rokutanda, Ryo
    Okada, Masato
    Matsushita, Masakazu
    Yamaji, Ken
    Tamura, Naoto
    CLINICAL MEDICINE INSIGHTS-ARTHRITIS AND MUSCULOSKELETAL DISORDERS, 2022, 15
  • [26] Community-acquired infection caused by small-colony variant of Staphylococcus aureus
    Rai, Sumit
    Sharma, Pramod Kumar
    Tyagi, Nirpex
    Agarwal, Sugandh
    INDIAN JOURNAL OF MEDICAL MICROBIOLOGY, 2020, 38 (02) : 216 - 218
  • [27] Small-colony variants and phenotype switching of intracellular Staphylococcus aureus in chronic rhinosinusitis
    Tan, N. C-W.
    Cooksley, C. M.
    Roscioli, E.
    Drilling, A. J.
    Douglas, R.
    Wormald, P-J.
    Vreugde, S.
    ALLERGY, 2014, 69 (10) : 1364 - 1371
  • [28] Persistence of a Staphylococcus aureus small-colony variant under antibiotic pressure in vivo
    Brouillette, E
    Martinez, A
    Boyll, BJ
    Allen, NE
    Malouin, F
    FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2004, 41 (01): : 35 - 41
  • [29] Characterization of Staphylococcus aureus small colony variant strains isolated from Italian patients attending a regional cystic fibrosis care centre
    Morelli, Patrizia
    De Alessandri, Alessandra
    Manno, Graziana
    Marchese, Anna
    Bandettini, Roberto
    Bassi, Marta
    Lobello, Raffaele
    Minicucci, Laura
    NEW MICROBIOLOGICA, 2015, 38 (02) : 235 - 243
  • [30] Does Trimethoprim-Sulfamethoxazole prophylaxis induce myelosuppression in primary immune deficiency disease patients; A retrospective, 3 groups comparative study
    Elajez, Reem
    Nisar, Sabha
    Adeli, Mehdi
    ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY, 2023, 41 (04) : 353 - 360