Efficient synthesis of quinoxalines with hypervalent iodine as a catalyst

被引：48

作者：

Chen, Chung-Yu ^{[2
]}

Hu, Wan-Ping ^{[3
]}

Liu, Mei-Chun ^{[1
]}

Yan, Pi-Cheng ^{[1
]}

Wang, Jeh-Jeng ^{[1
]}

Chung, Mei-Ing ^{[2
]}

机构：

[1] Kaohsiung Med Univ, Dept Med & Appl Chem, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan

[3] Kaohsiung Med Univ, Dept Biotechnol, Kaohsiung 807, Taiwan

来源：

TETRAHEDRON | 2013年 / 69卷 / 46期

关键词：

Quinoxaline; PhI(OAc)(2); Combretastatin A4; One-pot reaction; Anti-cancer; ONE-POT SYNTHESIS; SCHIFF-BASE COMPLEX; ANTICANCER ACTIVITY; GROWTH-INHIBITORS; ROOM-TEMPERATURE; MOLECULAR-OXYGEN; DERIVATIVES; OXIDATION; ALKYNES; DMSO;

D O I：

10.1016/j.tet.2013.09.027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various biologically important quinoxalines were efficiently synthesized in excellent yields via one-pot reaction between 1,2-diaminobenzenes and internal alkynes. The method utilizes inexpensive and readily available hypervalent iodine source, such as (diacetoxyiodo)benzene (PhI(OAc)(2)) and proved to be a better alternative as compared to expensive transition metal catalysts. Quinoxaline 4i [(2-phenyl-3-(3,4,5-trimethoxy phenyl)quinoxaline)] was evaluated for leukemia cancer cell lines and turned out to be a good candidate. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：9735 / 9741

页数：7

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