Expression of Indian Hedgehog signaling molecules in breast cancer

被引：43
|
作者：
Xuan, Yanhua [1 ]
Lin, Zhenhua [1 ,2 ]
机构：
[1] Yanbian Univ, Coll Med, Dept Pathol, Yanji 133000, Jilin, Peoples R China
[2] Yanbian Univ, Key Lab Nat Resources Changbai Mt & Funct Mol, Minist Educ, Yanji, Peoples R China
来源：
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2009年 / 135卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Hedgehog; Patched; Smoothened; Gli; Breast cancer; PATHWAY; TUMORS; GLI; GENES;
D O I：
10.1007/s00432-008-0451-x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To investigate the clinicopathological significance and expression pattern of Hedgehog (Hh) signaling molecules in breast normal glands and invasive ductal carcinoma. A total of 142 cases, including 21 of normal breast and 121 of invasive ductal carcinoma of the breast, were immunohistochemically analyzed for Ihh, Ptch, Smo, Gli-1, Gli-2, and Gli-3 protein expression. All of Hh signaling molecules were greatly enhanced in invasive ductal carcinoma compared with the normal breast epithelia. The expressions of Ihh, Smo, and Gli-2 were increased in PR negative cases, and the expressions of Ihh, Ptch, and Gli-1/2/3 were statistically correlated with increased proliferating index of Ki-67 in invasive ductal carcinoma. Ihh and Gli-1/2/3 expressions were correlated with node metastasis. Additionally, the protein expressions of Ihh, Ptch, and Gli-2 were correlated with the clinical stage of breast cancer. Hedgehog signaling molecules play an important role in the progression of invasive ductal carcinoma of breast.
引用
收藏
页码：235 / 240
页数：6
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