SUMO: A Multifaceted Modifier of Chromatin Structure and Function

被引：206

作者：

Cubenas-Potts, Caelin ^{[1
]}

Matunis, Michael J. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Biochem & Mol Biol, Baltimore, MD 21205 USA

来源：

DEVELOPMENTAL CELL | 2013年 / 24卷 / 01期

基金：

美国国家卫生研究院;

关键词：

NOVO DNA METHYLTRANSFERASE; TRANSCRIPTIONAL REPRESSION; SACCHAROMYCES-CEREVISIAE; ANDROGEN RECEPTOR; TOPOISOMERASE-II; TELOMERE LENGTH; SMC5/6; COMPLEX; S-PHASE; SUMOYLATION; PROTEIN;

D O I：

10.1016/j.devcel.2012.11.020

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A major challenge in nuclear organization is the packaging of DNA into dynamic chromatin structures that can respond to changes in the transcriptional requirements of the cell. Posttranslational protein modifications, of histones and other chromatin-associated factors, are essential regulators of chromatin dynamics. In this Review, we summarize studies demonstrating that posttranslational modification of proteins by small ubiquitin-related modifiers (SUMOs) regulates chromatin structure and function at multiple levels and through a variety of mechanisms to influence gene expression and maintain genome integrity.

引用

页码：1 / 12

页数：12

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