The impairment of insulin signaling in Alzheimer's disease

被引：73

作者：

Candeias, Emanuel ^{[1
]}

Duarte, Ana I. ^{[1
]}

Carvalho, Cristina ^{[1
,2
]}

Correia, Sonia C. ^{[1
,2
]}

Cardoso, Susana ^{[1
,2
]}

Santos, Renato X. ^{[1
,2
]}

Placido, Ana I. ^{[1
]}

Perry, George ^{[4
]}

Moreira, Paula I. ^{[1
,3
]}

机构：

[1] Univ Coimbra, Ctr Neurosci & Cell Biol, P-3004517 Coimbra, Portugal

[2] Univ Coimbra, Fac Sci & Technol, Dept Life Sci, P-3004517 Coimbra, Portugal

[3] Univ Coimbra, Fac Med, Physiol Lab, P-3004517 Coimbra, Portugal

[4] Univ Texas San Antonio, Coll Sci, San Antonio, TX USA

来源：

IUBMB LIFE | 2012年 / 64卷 / 12期

关键词：

aging; Alzheimer's disease; type; 2; diabetes; insulin signaling; THERAPEUTIC TARGET; GLUCOSE-METABOLISM; BRAIN; RESISTANCE; MITOCHONDRIA; DYSFUNCTION; DEMENTIA; RECEPTOR; PATHWAY; RISK;

D O I：

10.1002/iub.1098

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alterations of the insulin signaling cascade underlie cognitive decline and the development of several neurodegenerative diseases. In recent years, a great interest has been put in studying the interaction between diabetes and Alzheimer's disease (AD). In fact, evidence shows that both diseases present several biochemical similarities including defects in the insulin signaling pathway. Here, we give an overview of the main functions of insulin in the central nervous system. The impact of insulin signaling impairment in brain aging and AD is also discussed. Finally, we present evidence supporting the notion that insulin is a link between diabetes and AD. (C) 2012 IUBMB IUBMB Life, 64(12): 951957, 2012

引用

页码：951 / 957

页数：7

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