Streptopyrrolidine, an angiogenesis inhibitor from a marine-derived Streptomyces sp KORDI-3973

被引：58

作者：

Shin, Hee Jae ^{[1
]}

Kim, Tae Sik ^{[1
]}

Lee, Hyi-Seung ^{[1
]}

Park, Jung Youl ^{[2
]}

Choi, In-Kwon ^{[3
]}

Kwon, Ho Jeong ^{[3
]}

机构：

[1] Korea Ocean Res & Dev Inst, Marine Nat Prod Lab, Seoul 425600, South Korea

[2] C&C Res Labs, Hwasung Si 445976, Kyunggi Do, South Korea

[3] Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Chem Genom Lab, Seoul 120749, South Korea

来源：

PHYTOCHEMISTRY | 2008年 / 69卷 / 12期

关键词：

Streptomyces sp KORDI-3973; angiogenesis inhibitors; streptopyrrolidine; 5-benzyl-4-hydroxypyrrolidin-2-one; bioactive natural products;

D O I：

10.1016/j.phytochem.2008.05.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Streptopyrrolidine, a benzyl pyrrolidine derivative, was isolated as an angiogenesis inhibitor from the fermentation broth of a marine Streptomyces sp. isolated from the deep sea sediment. its structure was elucidated by extensive 2D NMR and mass spectroscopic analyses. Streptopyrrolidine exhibited significant anti-angiogenesis activity. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2363 / 2366

页数：4

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