The anatomical problem posed by brain complexity and size: a potential solution

被引：38
作者：
DeFelipe, Javier [1 ,2 ]
机构：
[1] CSIC, Inst Cajal, Ctr Tecnol Biomed UPM, Lab Cajal Circuitos Corticales, E-28002 Madrid, Spain
[2] CIBERNED, Madrid, Spain
来源：
FRONTIERS IN NEUROANATOMY | 2015年 / 9卷
关键词：
neuron doctrine; electron microscopy; connectome; synaptome; choice of species for studying brain; interdisciplinary approaches; QUANTITATIVE DENDRITIC ANALYSIS; CEREBRAL-CORTEX; INTERINDIVIDUAL VARIABILITY; CIRCUIT RECONSTRUCTION; VOLUME TRANSMISSION; PYRAMIDAL NEURON; SEX-DIFFERENCES; NERVOUS-SYSTEM; VISUAL-CORTEX; WERNICKE AREA;
D O I：
10.3389/fnana.2015.00104
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Over the years the field of neuroanatomy has evolved considerably but unraveling the extraordinary structural and functional complexity of the brain seems to be an unattainable goal, partly due to the fact that it is only possible to obtain an imprecise connection matrix of the brain. The reasons why reaching such a goal appears almost impossible to date is discussed here, together with suggestions of how we could overcome this anatomical problem by establishing new methodologies to study the brain and by promoting interdisciplinary collaboration. Generating a realistic computational model seems to be the solution rather than attempting to fully reconstruct the whole brain or a particular brain region.
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页数：16
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