Pseudoalteromone B: A Novel 15C Compound from a Marine Bacterium Pseudoalteromonas sp CGH2XX

被引：9

作者：

Chen, Yu-Hsin ^{[1
,2
,3
,4
]}

Kuo, Jimmy ^{[3
,4
]}

Su, Jui-Hsin ^{[3
,4
]}

Hwang, Tsong-Long ^{[5
]}

Chen, Yung-Husan ^{[4
]}

Lee, Chia-Hung ^{[1
,2
,3
]}

Weng, Ching-Feng ^{[1
,2
,3
]}

Sung, Ping-Jyun ^{[1
,2
,3
,4
,6
,7
]}

机构：

[1] Natl Dong Hwa Univ, Dept Life Sci, Hualien 974, Taiwan

[2] Natl Dong Hwa Univ, Inst Biotechnol, Hualien 974, Taiwan

[3] Natl Dong Hwa Univ, Grad Inst Marine Biotechnol, Pingtung 944, Taiwan

[4] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[5] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan

[6] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[7] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Div Marine Biotechnol, Kaohsiung 804, Taiwan

来源：

MARINE DRUGS | 2012年 / 10卷 / 07期

关键词：

pseudoalteromone; Pseudoalteromonas; anti-inflammatory; Lobophytum crassum; elastase; TUMOR-CELL-LINES; ASSAY;

D O I：

10.3390/md10071566

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel 15C compound, pseudoalteromone B (1), possessing a novel carbon skeleton, was obtained from a marine bacterium Pseudoalteromonas sp. CGH2XX. This bacterium was originally isolated from a cultured-type octocoral Lobophytum crassum, that was growing in cultivating tanks equipped with a flow-through sea water system. The structure of 1 was established by spectroscopic methods. Pseudoalteromone B (1) displayed a modestly inhibitory effect on the release of elastase by human neutrophils.

引用

页码：1566 / 1571

页数：6

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