Pulmonary well-differentiated fetal adenocarcinoma with platelet-derived growth factor receptor (PDGFR)α expression

被引：3

作者：

Luo, Can-Qiao ^{[2
]}

Yeung, Sai-Ching J. ^{[3
,4
]}

Liu, Zhen-Guo ^{[1
]}

Meng, Jun ^{[1
]}

Zhong, Fo-tian ^{[1
]}

Cheng, Chao ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Thorac Surg, Guangzhou 510275, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Pathol, Guangzhou 510275, Guangdong, Peoples R China

[3] Univ Texas MD Anderson Canc Ctr, Dept Emergency Med, Houston, TX 77030 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX 77030 USA

来源：

CANCER BIOLOGY & THERAPY | 2012年 / 13卷 / 14期

关键词：

well-differentiated fetal adenocarcinoma; PDGFR alpha; surgery; lung cancer; WDFA; beta-catenin; GASTROINTESTINAL STROMAL TUMORS; LUNG; BLASTOMA; PDGFRA; CELLS; ACTIVATION; MUTATIONS; IMATINIB; KINASE; SIGNAL;

D O I：

10.4161/cbt.22253

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Well-differentiated fetal adenocarcinoma (WDFA) is a rare pulmonary malignancy. Biomarkers of tumor biology has rarely been studied in WDFA. Here, we report two WDFA patients. Both patients had blood-streaked sputum or mild hemoptysis at presentation. They underwent lobectomy and systematic mediastinal lymphadenectomy. Expression of PDGFR alpha on the plasma membrane was demonstrated by immunohistochemistry (IHC) in the resected tumor specimens. Further IHC examination showed intense immunostaining of beta-catenin in both patients but negative staining for TP53, CEA, CD56, EGFR, CK5/6, HER2, S-100, ER, PR, BCL2 and NSE. Both patients had no recurrence to date after more than 3 years of follow up. Herein, we reviewed this rare disease with special emphasis on the clinico-pathological features, treatment and potential role of PDGFR alpha.

引用

页码：1384 / 1389

页数：6

共 29 条

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