Collagen VI Encodes Antimicrobial Activity: Novel Innate Host Defense Properties of the Extracellular Matrix

被引：14

作者：

Abdillahi, Suado M. ^{[1
]}

Balvanovic, Selma ^{[1
]}

Baumgarten, Maria ^{[1
]}

Morgelin, Matthias ^{[1
]}

机构：

[1] Lund Univ, Biomed Ctr, Dept Clin Sci, Div Infect Med, SE-22184 Lund, Sweden

来源：

JOURNAL OF INNATE IMMUNITY | 2012年 / 4卷 / 04期

基金：

瑞典研究理事会;

关键词：

Antimicrobial activity; Innate host defense; Collagen type VI; Extracellular matrix; Streptococcus; Oral pathogens; HEPARIN-BINDING PEPTIDES; GROUP-G STREPTOCOCCI; SURFACE PROTEIN; GROUP-C; CHAINS; HYALURONAN; PYOGENES; LAMININ;

D O I：

10.1159/000335239

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Collagen type VI is a subepithelial extracellular matrix component in airways and an adhesive substrate for oral pathogens [Bober et al.: J Innate lmmun 2010;2:160-166]. Here, we report that collagen VI displays a dose-dependent antimicrobial activity against group A, C, and G streptococci by membrane disruption in physiological conditions. The data disclose previously unrecognized aspects of the extracellular matrix in innate host defense. Copyright (C) 20125. Karger AG, Basel

引用

页码：371 / 376

页数：6

共 26 条

[1] Antimicrobial activities of heparin-binding peptides [J].

Andersson, E ;

Rydengård, V ;

Sonesson, A ;

Mörgelin, M ;

Björck, L ;

Schmidtchen, A .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2004, 271 (06) :1219-1226

[2] Collagen VI Is a Subepithelial Adhesive Target for Human Respiratory Tract Pathogens [J].

Bober, Marta ;

Enochsson, Charlotte ;

Collin, Mattias ;

Morgelin, Matthias .

JOURNAL OF INNATE IMMUNITY, 2010, 2 (02) :160-166

[3] Antibacterial activity within degradation products of biological scaffolds composed of extracellular matrix [J].

Brennan, Ellen P. ;

Reing, Janet ;

Chew, Douglas ;

Myers-Irvin, Julie M. ;

Young, E. J. ;

Badylak, Stephen F. .

TISSUE ENGINEERING, 2006, 12 (10) :2949-2955

[4] Streptococcus pyogenes recruits collagen via surface-bound fibronectin:: a novel colonization and immune evasion mechanism [J].

Dinkla, K ;

Rohde, M ;

Jansen, WMT ;

Carapetis, JR ;

Chhatwal, GS ;

Talay, SR .

MOLECULAR MICROBIOLOGY, 2003, 47 (03) :861-869

[5] Three novel collagen VI chains, α4(VI), α5(VI), and α6(VI) [J].

Fitzgerald, Jamie ;

Rich, Cathleen ;

Zhou, Fiona H. ;

Hansen, Uwe .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (29) :20170-20180

[6] Differential and restricted expression of novel collagen VI chains in mouse [J].

Gara, Sudheer Kumar ;

Grumati, Paolo ;

Squarzoni, Stefano ;

Sabatelli, Patrizia ;

Urciuolo, Anna ;

Bonaldo, Paolo ;

Paulsson, Mats ;

Wagener, Raimund .

MATRIX BIOLOGY, 2011, 30 (04) :248-257

[7] Pharyngeal carriage of group C and group G streptococci and acute rheumatic fever in an Aboriginal population [J].

Haidan, A ;

Talay, SR ;

Rohde, M ;

Sriprakash, KS ;

Currie, BJ ;

Chhatwal, GS .

LANCET, 2000, 356 (9236) :1167-1169

[8] Haemophilus influenzae Protein E Binds to the Extracellular Matrix by Concurrently Interacting With Laminin and Vitronectin [J].

Hallstrom, Teresia ;

Singh, Birendra ;

Resman, Fredrik ;

Blom, Anna M. ;

Morgelin, Matthias ;

Riesbeck, Kristian .

JOURNAL OF INFECTIOUS DISEASES, 2011, 204 (07) :1065-1074

[9] The C-Terminal Sequence of Several Human Serine Proteases Encodes Host Defense Functions [J].

Kasetty, Gopinath ;

Papareddy, Praveen ;

Kalle, Martina ;

Rydengard, Victoria ;

Walse, Bjorn ;

Svensson, Bo ;

Morgelin, Matthias ;

Malmsten, Martin ;

Schmidtchen, Artur .

JOURNAL OF INNATE IMMUNITY, 2011, 3 (05) :471-482

[10]

Kihlberg BM, 1999, INFECT IMMUN, V67, P1708

← 1 2 3 →