Mighty Minipig in Fight Against Cardiovascular Disease

被引:12
作者
Agarwala, Anandita [1 ]
Billheimer, Jeffrey [1 ]
Rader, Daniel J. [1 ]
机构
[1] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA
关键词
D O I
10.1126/scitranslmed.3005369
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
A cloned transgenic minipig model of hypercholesterolemia and accelerated atherosclerosis could accelerate discovery of new therapies for atherosclerotic cardiovascular disease.
引用
收藏
页数:3
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共 10 条
[1]   Familial Hypercholesterolemia and Atherosclerosis in Cloned Minipigs Created by DNA Transposition of a Human PCSK9 Gain-of-Function Mutant [J].
Al-Mashhadi, Rozh H. ;
Sorensen, Charlotte B. ;
Kragh, Peter M. ;
Christoffersen, Christina ;
Mortensen, Martin B. ;
Tolbod, Lars P. ;
Thim, Troels ;
Du, Yutao ;
Li, Juan ;
Liu, Ying ;
Moldt, Brian ;
Schmidt, Mette ;
Vajta, Gabor ;
Larsen, Torben ;
Purup, Stig ;
Bolund, Lars ;
Nielsen, Lars B. ;
Callesen, Henrik ;
Falk, Erling ;
Mikkelsen, Jacob Giehm ;
Bentzon, Jacob F. .
SCIENCE TRANSLATIONAL MEDICINE, 2013, 5 (166)
[2]   Large-scale association analysis identifies new risk loci for coronary artery disease [J].
Deloukas, Panos ;
Kanoni, Stavroula ;
Willenborg, Christina ;
Farrall, Martin ;
Assimes, Themistocles L. ;
Thompson, John R. ;
Ingelsson, Erik ;
Saleheen, Danish ;
Erdmann, Jeanette ;
Goldstein, Benjamin A. ;
Stirrups, Kathleen ;
Koenig, Inke R. ;
Cazier, Jean-Baptiste ;
Johansson, Asa ;
Hall, Alistair S. ;
Lee, Jong-Young ;
Willer, Cristen J. ;
Chambers, John C. ;
Esko, Tonu ;
Folkersen, Lasse ;
Goel, Anuj ;
Grundberg, Elin ;
Havulinna, Aki S. ;
Ho, Weang K. ;
Hopewell, Jemma C. ;
Eriksson, Niclas ;
Kleber, Marcus E. ;
Kristiansson, Kati ;
Lundmark, Per ;
Lyytikainen, Leo-Pekka ;
Rafelt, Suzanne ;
Shungin, Dmitry ;
Strawbridge, Rona J. ;
Thorleifsson, Gudmar ;
Tikkanen, Emmi ;
Van Zuydam, Natalie ;
Voight, Benjamin F. ;
Waite, Lindsay L. ;
Zhang, Weihua ;
Ziegler, Andreas ;
Absher, Devin ;
Altshuler, David ;
Balmforth, Anthony J. ;
Barroso, Ines ;
Braund, Peter S. ;
Burgdorf, Christof ;
Claudi-Boehm, Simone ;
Cox, David ;
Dimitriou, Maria ;
Do, Ron .
NATURE GENETICS, 2013, 45 (01) :25-U52
[3]   Animal Models of Atherosclerosis [J].
Getz, Godfrey S. ;
Reardon, Catherine A. .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2012, 32 (05) :1104-+
[4]   PCSK9: a convertase that coordinates LDL catabolism [J].
Horton, Jay D. ;
Cohen, Jonathan C. ;
Hobbs, Helen H. .
JOURNAL OF LIPID RESEARCH, 2009, 50 :S172-S177
[5]   Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research: Novel Atherosclerosis Model Induced by High Fat and Cholesterol Diet [J].
Kawaguchi, Hiroaki ;
Miyoshi, Noriaki ;
Miura, Naoki ;
Fujiki, Makoto ;
Horiuchi, Masahisa ;
Izumi, Yasukatsu ;
Miyajima, Hiroaki ;
Nagata, Ryoichi ;
Misumi, Kazuhiro ;
Takeuchi, Toru ;
Tanimoto, Akihide ;
Yoshida, Hiroki .
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 115 (02) :115-121
[6]   A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits [J].
Okamoto, H ;
Yonemori, F ;
Wakitani, K ;
Minowa, T ;
Maeda, K ;
Shinkai, H .
NATURE, 2000, 406 (6792) :203-207
[7]   Effects of Dalcetrapib in Patients with a Recent Acute Coronary Syndrome [J].
Schwartz, Gregory G. ;
Olsson, Anders G. ;
Abt, Markus ;
Ballantyne, Christie M. ;
Barter, Philip J. ;
Brumm, Jochen ;
Chaitman, Bernard R. ;
Holme, Ingar M. ;
Kallend, David ;
Leiter, Lawrence A. ;
Leitersdorf, Eran ;
McMurray, John J. V. ;
Mundl, Hardi ;
Nicholls, Stephen J. ;
Shah, Prediman K. ;
Tardif, Jean-Claude ;
Wright, R. Scott .
NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (22) :2089-2099
[8]   The synergistic inhibition of atherogenesis in apoE-/- mice between pravastatin and the sPLA2 inhibitor varespladib (A-002) [J].
Shaposhnik, Zory ;
Wang, Xuping ;
Trias, Joaquim ;
Fraser, Heather ;
Lusis, Aldons J. .
JOURNAL OF LIPID RESEARCH, 2009, 50 (04) :623-629
[9]   Effects of succinobucol (AGI-1067) after an acute coronary syndrome: a randomised, double-blind, placebo-controlled trial [J].
Tardif, Jean-Claude ;
McMurray, John J. V. ;
Klug, Eric ;
Small, Robert ;
Schumi, Jennifer ;
Choi, Jasmine ;
Cooper, Jim ;
Scott, Robert ;
Lewis, Eldrin F. ;
L'Allier, Philippe L. ;
Pfeffer, Marc A. .
LANCET, 2008, 371 (9626) :1761-1768
[10]   Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development [J].
Wilensky, Robert L. ;
Shi, Yi ;
Mohler, Emile R., III ;
Hamamdzic, Damir ;
Burgert, Mark E. ;
Li, Jun ;
Postle, Anthony ;
Fenning, Robert S. ;
Bollinger, James G. ;
Hoffman, Bryan E. ;
Pelchovitz, Daniel J. ;
Yang, Jisheng ;
Mirabile, Rosanna C. ;
Webb, Christine L. ;
Zhang, LeFeng ;
Zhang, Ping ;
Gelb, Michael H. ;
Walker, Max C. ;
Zalewski, Andrew ;
Macphee, Colin H. .
NATURE MEDICINE, 2008, 14 (10) :1059-1066