Mast Cells, Angiogenesis and Lymphangiogenesis in Human Gastric Cancer

被引：162

作者：

Sammarco, Giuseppe ^{[1
]}

Varricchi, Gilda ^{[2
,3
,4
]}

Ferraro, Valentina ^{[5
]}

Ammendola, Michele ^{[1
]}

De Fazio, Michele ^{[6
]}

Altomare, Donato Francesco ^{[6
]}

Luposella, Maria ^{[7
]}

Maltese, Lorenza ^{[8
]}

Curro, Giuseppe ^{[1
,9
]}

Marone, Gianni ^{[2
,3
,4
,10
]}

Ranieri, Girolamo ^{[11
]}

Memeo, Riccardo ^{[6
]}

机构：

[1] Magna Graecia Univ Catanzaro, Med Sch Germaneto, Dept Hlth Sci, Gen Surg, I-88100 Catanzaro, Italy

[2] Univ Naples Federico II, Dept Translat Med Sci DISMET, I-80131 Naples, Italy

[3] Univ Naples Federico II, Ctr Basic & Clin Immunol Res CISI, I-80131 Naples, Italy

[4] WAO Ctr Excellence, I-80131 Naples, Italy

[5] Aldo Moro Univ, Dept Biomed Sci & Human Oncol, Unit Endocrine Digest & Emergency Surg, I-74124 Bari, Italy

[6] Aldo Moro Univ, Dept Emergency & Organ Transplantat, I-74124 Bari, Italy

[7] San Giovanni Dio Hosp, Cardiovasc Dis Unit, I-88900 Crotone, Italy

[8] Pugliese Ciaccio Hosp, Pathol Unit, I-88100 Catanzaro, Italy

[9] Univ Messina, Dept Human Pathol Adult & Evolut Age G Barresi, I-98122 Messina, Italy

[10] Natl Res Council CNR, Inst Expt Endocrinol & Oncol IEOS, I-80131 Naples, Italy

[11] Ist Tumori Giovanni Paolo II, Natl Canc Res Ctr, Intervent Oncol Unit, Integrated Sect Translat Med Oncol, I-74124 Bari, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 09期

关键词：

angiogenesis; cancer; gastric cancer; immune cells; inflammation; lymphangiogenesis; mast cells; ENDOTHELIAL GROWTH-FACTOR; PROTEASE-ACTIVATED RECEPTOR-2; VASCULAR-PERMEABILITY FACTOR; FREE LIGHT-CHAINS; MICROVASCULAR DENSITY; TUMOR ANGIOGENESIS; POOR-PROGNOSIS; TH17; CELLS; MOLECULAR CLASSIFICATION; PROTUMORIGENIC ROLE;

D O I：

10.3390/ijms20092106

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gastric cancer is diagnosed in nearly one million new patients each year and it remains the second leading cause of cancer-related deaths worldwide. Although gastric cancer represents a heterogeneous group of diseases, chronic inflammation has been shown to play a role in tumorigenesis. Cancer development is a multistep process characterized by genetic and epigenetic alterations during tumour initiation and progression. The stromal microenvironment is important in maintaining normal tissue homeostasis or promoting tumour development. A plethora of immune cells (i.e., lymphocytes, macrophages, mast cells, monocytes, myeloid-derived suppressor cells, Treg cells, dendritic cells, neutrophils, eosinophils, natural killer (NK) and natural killer T (NKT) cells) are components of gastric cancer microenvironment. Mast cell density is increased in gastric cancer and there is a correlation with angiogenesis, the number of metastatic lymph nodes and the survival of these patients. Mast cells exert a protumorigenic role in gastric cancer through the release of angiogenic (VEGF-A, CXCL8, MMP-9) and lymphangiogenic factors (VEGF-C and VEGF-F). Gastric mast cells express the programmed death ligands (PD-L1 and PD-L2) which are relevant as immune checkpoints in cancer. Several clinical undergoing trials targeting immune checkpoints could be an innovative therapeutic strategy in gastric cancer. Elucidation of the role of subsets of mast cells in different human gastric cancers will demand studies of increasing complexity beyond those assessing merely mast cell density and microlocalization.

引用

页数：22

共 240 条

[1] Prostaglandin E2 induces degranulation-independent production of vascular endothelial growth factor by human mast cells [J].