Pro- and antioxidant properties of uracil derivatives

被引：13
作者：
Murinov, Yu. I. [1 ]
Grabovskii, S. A. [1 ]
Kabal'nova, N. N. [1 ]
机构：
[1] Russian Acad Sci, Ufa Fed Res Ctr, Ufa Inst Chem, 71 Prosp Oktyabrya, Ufa 450054, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2019年 / 68卷 / 05期
关键词：
uracil derivatives; antioxidants; prooxidants; variable-valence metal ions; fixation and activation of molecular oxygen; reactive oxygen species; RADICAL-CHAIN OXIDATION; MOLECULAR-OXYGEN; BIOLOGICAL-ACTIVITY; EFFICIENT SCAVENGER; 5-AMINOOROTIC ACID; COMPLEX-FORMATION; COPPER(II) IONS; URIC-ACID; 5-HYDROXY-6-METHYLURACIL; 5-AMINOURACIL;
D O I：
10.1007/s11172-019-2505-4
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The review summarizes data on pro- and antioxidant properties of uracil derivatives comprising an important group of pharmacologically active compounds. The presence of OH or NH2 groups at position 5 of the uracil ring was shown to be essential for these compounds to have both antioxidant and prooxidant properties. The mechanism of pro- and antioxidant action is discussed.
引用
收藏
页码：946 / 954
页数：9
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