Fractional flow reserve in clinical practice: from wire-based invasive measurement to image-based computation

被引：77

作者：

Tu, Shengxian ^{[1
]}

Westra, Jelmer ^{[2
]}

Adjedj, Julien ^{[3
,4
]}

Ding, Daixin ^{[1
]}

Liang, Fuyou ^{[5
,6
]}

Xu, Bo ^{[7
]}

Holm, Niels Ramsing ^{[2
]}

Reiber, Johan H. C. ^{[8
]}

Wijns, William ^{[9
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Biomed Engn, 1954 Hua Shan Rd, Shanghai 200030, Peoples R China

[2] Aarhus Univ Hosp, Dept Cardiol, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark

[3] Arnault Tzanck Inst, Cardiol Dept, 171 Rue Commandant Gaston Cahuzac, F-06700 St Laurent Du Var, France

[4] CHU Vaudois, Cardiol Dept, Rue Bugnon 46, CH-1011 Lausanne, Switzerland

[5] Shanghai Jiao Tong Univ, Sch Naval Architecture Ocean & Civil Engn, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

[6] Sechenov Univ, Inst Personalized Med, 8-2 Trubetskaya St, Moscow 119991, Russia

[7] Chinese Acad Med Sci, Fu Wai Hosp, Natl Ctr Cardiovasc Dis, Natl Clin Res Ctr Cardiovasc Dis,Catheterizat Lab, A 167,Beilishi Rd, Beijing 100037, Peoples R China

[8] Leiden Univ, Dept Radiol, Div Image Proc, Med Ctr, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands

[9] Natl Univ Ireland Galway, Lambe Inst Translat Med & Curam, Univ Rd, Galway H91 TK3, Ireland

来源：

EUROPEAN HEART JOURNAL | 2020年 / 41卷 / 34期

基金：

爱尔兰科学基金会;

关键词：

Fractional flow reserve; Myocardial ischaemia; Coronary artery disease; IVUS; OCT and coronary angiogram; DIAGNOSTIC-ACCURACY; CORONARY-ANGIOGRAPHY; PRESSURE MEASUREMENTS; STENOSIS SEVERITY; RATIO;

D O I：

10.1093/eurheartj/ehz918

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fractional flow reserve (FFR) and instantaneous wave-free ratio are the present standard diagnostic methods for invasive assessment of the functional significance ofepicardial coronary stenosis. Despite the overall trend towards more physiology-guided revasculari-zati-on, there remains a gap, between guideline recommendations and the clinical adoption of functional evaItAatiorl of stenosis severity. A number of image-based approaches have been proposed to compute FFR without the use of pressure wire and induced hyperaemia. In order to better understand these emerging technologi'es, we sought to highlight the pri'nci'ples, diagnostic performance, clinical applications, practical aspects, and current challenges of computational physiology in the catheterization Laboratory. Computational FFR has the potential to ex Pand and facilitate the use of physiology for diagnosis, procedural guidance, and evaluation of therapies, with anticipated impact on resource utilization and patient outcomes.

引用

页码：3271 / 3279

页数：9

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