Dopaminergic Neuronal Imaging in Genetic Parkinson's Disease: Insights into Pathogenesis

被引：58

作者：

McNeill, Alisdair ^{[1
,2
]}

Wu, Ruey-Meei ^{[3
]}

Tzen, Kai-Yuan ^{[4
]}

Aguiar, Patricia C. ^{[5
]}

Arbelo, Jose M. ^{[6
]}

Barone, Paolo ^{[7
]}

Bhatia, Kailash ^{[8
]}

Barsottini, Orlando ^{[9
]}

Bonifati, Vincenzo ^{[10
]}

Bostantjopoulou, Sevasti ^{[11
]}

Bressan, Rodrigo ^{[5
]}

Cossu, Giovanni ^{[12
,13
]}

Cortelli, Pietro ^{[14
]}

Felicio, Andre ^{[5
]}

Ferraz, Henrique B. ^{[15
]}

Herrera, Joanna ^{[17
]}

Houlden, Henry ^{[16
]}

Hoexter, Marcelo ^{[5
]}

Isla, Concepcion ^{[17
]}

Lees, Andrew ^{[8
]}

Lorenzo-Betancor, Oswaldo ^{[17
]}

Mencacci, Niccolo E. ^{[16
]}

Pastor, Pau ^{[17
]}

Pappata, Sabina ^{[18
]}

Pellecchia, Maria Teresa ^{[7
]}

Silveria-Moriyama, Laura ^{[8
]}

Varrone, Andrea ^{[18
,19
]}

Foltynie, Tom ^{[8
]}

Schapira, Anthony H. V. ^{[1
]}

机构：

[1] UCL, Dept Clin Neurosci, Inst Neurol, London, England

[2] Birmingham Womens Hosp, Reg Genet Unit, Dept Clin Genet, Birmingham, W Midlands, England

[3] Natl Taiwan Univ Hosp, Coll Med, Dept Neurol, Taipei, Taiwan

[4] Natl Taiwan Univ Hosp, Coll Med, Dept Nucl Med, Taipei, Taiwan

[5] Hosp Israelita Albert Einstein, Inst Israelita Ensino & Pesquisa Albert Einstein, Sao Paulo, Brazil

[6] Hosp Univ Insular Gran Canaria, Dept Neurol, Parkinsons & Movement Disorders Unit, Las Palmas Gran Canaria, Spain

[7] Univ Salerno, Ctr Neurodegenerat Dis, Salerno, Fisciano Provin, Italy

[8] UCL, Inst Neurol, Sobell Dept Motor Sci, London, England

[9] Univ Fed Sao Paulo, Dept Neurol, Sao Paulo, Brazil

[10] Erasmus MC, Dept Clin Genet, Rotterdam, Netherlands

[11] Aristotle Univ Thessaloniki, G Papanikolaou Hosp, Dept Neurol 3, GR-54006 Thessaloniki, Greece

[12] Gen Hosp S Michele AOB G Brotzu, Neurol Serv, Cagliari, Italy

[13] Gen Hosp S Michele AOB G Brotzu, Stroke Unit, Cagliari, Italy

[14] Univ Bologna, Dept Biomed & Neuromotor Sci, Bologna, Italy

[15] Univ Fed Sao Paulo UNIFESP, EPM, Div Movement Disorders, Sao Paulo, Brazil

[16] UCL Inst Neurol, Dept Mol Neurosci, London, England

[17] Univ Navarra, Div Neurosci, Ctr Appl Med Res, Neurogenet Lab, E-31080 Pamplona, Spain

[18] CNR, Inst Biostruct & Bioimaging, I-80125 Naples, Italy

[19] Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden

来源：

PLOS ONE | 2013年 / 8卷 / 07期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

ALPHA-SYNUCLEIN GENE; GLUCOCEREBROSIDASE MUTATION; NIGROSTRIATAL DYSFUNCTION; PET; CARRIERS; LRRK2; I-123-FP-CIT; DUPLICATION; TRANSPORTER; PROGRESSION;

D O I：

10.1371/journal.pone.0069190

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Objectives: To compare the dopaminergic neuronal imaging features of different subtypes of genetic Parkinson's Disease. Methods: A retrospective study of genetic Parkinson's diseases cases in which DaTSCAN (123I-FP-CIT) had been performed. Specific non-displaceable binding was calculated for bilateral caudate and putamen for each case. The right: left asymmetry index and striatal asymmetry index was calculated. Results: Scans were available from 37 cases of monogenetic Parkinson's disease (7 glucocerebrosidase (GBA) mutations, 8 alpha-synuclein, 3 LRRK2, 7 PINK1, 12 Parkin). The asymmetry of radioligand uptake for Parkinson's disease with GBA or LRRK2 mutations was greater than that for Parkinson's disease with alpha synuclein, PINK1 or Parkin mutations. Conclusions: The asymmetry of radioligand uptake in Parkinsons disease associated with GBA or LRRK2 mutations suggests that interactions with additional genetic or environmental factors may be associated with dopaminergic neuronal loss.

引用

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