2-Trifluoromethylated Indoles via Radical Trifluoromethylation of Isonitriles

被引：132

作者：

Zhang, Bo ^{[1
]}

Studer, Armido ^{[1
]}

机构：

[1] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 04期

关键词：

COPPER-CATALYZED TRIFLUOROMETHYLATION; BETA-KETO-ESTERS; C-H ACTIVATION; BOND FORMATION; PHENANTHRIDINE DERIVATIVES; BEARING METHOXYCARBONYL; OXIDATIVE CYCLIZATION; AROMATIC-COMPOUNDS; CARBOXYLIC-ACIDS; FUNCTIONALIZATION;

D O I：

10.1021/ol5001395

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Either two or three C-C bonds are formed in the synthesis of 2-trifluoromethylindoles starting with readily prepared isonitriles and the Togni reagent as CF3 radical precursor. These transformations occur in the absence of transition metal, and products are obtained in moderate to good yields with excellent diastereoselectivity.

引用

页码：1216 / 1219

页数：4

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