Bioactive Silicate Nanoplatelets for Osteogenic Differentiation of Human Mesenchymal Stem Cells

被引：452

作者：

Gaharwar, Akhilesh K. ^{[1
,2
,3
]}

Mihaila, Silvia M. ^{[1
,4
,5
,6
]}

Swami, Archana ^{[2
,7
]}

Patel, Alpesh ^{[1
,4
]}

Sant, Shilpa ^{[1
,3
,4
]}

Reis, Rui L. ^{[5
,6
]}

Marques, Alexandra P. ^{[5
,6
]}

Gomes, Manuela E. ^{[5
,6
]}

Khademhosseini, Ali ^{[1
,3
,4
]}

机构：

[1] Harvard Univ, Sch Med, Ctr Biomed Engn, Brigham & Womens Hosp, Cambridge, MA 02115 USA

[2] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[3] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA

[4] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[5] Univ Minho, Res Grp Biomat Biodegradables & Biomimet 3Bs, Dept Polymer Engn, P-4806909 Taipas, Guimaraes, Portugal

[6] ICVS 3Bs PT Govt Associate Lab, P-4806909 Braga, Portugal

[7] Harvard Univ, Sch Med, Brigham & Womens Hosp, Lab Nanomed & Biomat, Boston, MA 02115 USA

来源：

ADVANCED MATERIALS | 2013年 / 25卷 / 24期

基金：

美国国家科学基金会; 加拿大自然科学与工程研究理事会; 美国国家卫生研究院;

关键词：

synthetic clay; laponite nanoparticles; human mesenchymal stem cells; osteogenic differentiation; tissue engineering; OSTEOBLASTIC DIFFERENTIATION; NANOCOMPOSITE FILMS; DESIGNING MATERIALS; IN-VITRO; CLAY; BONE; NANOPARTICLES; HYDROGELS; GELS; CYTOTOXICITY;

D O I：

10.1002/adma.201300584

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel silicate nanoplatelets that induce osteogenic differentiation of human mesenchymal stem cells (hMSCs) in the absence of any osteoinductive factor are reported. The presence of the silicate triggers a set of events that follows the temporal pattern of osteogenic differentiation. These findings underscore the potential applications of these silicate nanoplatelets in designing bioactive scaffolds for musculoskeletal tissue engineering. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3329 / 3336

页数：8

共 49 条

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