RECALCITRANT MACULAR EDEMA AFTER INTRAVITREAL BEVACIZUMAB IS RESPONSIVE TO AN INTRAVITREAL DEXAMETHASONE IMPLANT IN RETINAL VEIN OCCLUSION

被引：20

作者：

Sharareh, Behnam ^{[1
,2
]}

Gallemore, Ron ^{[1
]}

Taban, Mehran ^{[1
]}

Onishi, Spencer ^{[1
]}

Wallsh, Josh ^{[1
]}

机构：

[1] Retina Macula Inst, Torrance, CA 90503 USA

[2] Univ Calif Irvine, Sch Med, Irvine, CA 92717 USA

来源：

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2013年 / 33卷 / 06期

关键词：

retinal vein occlusion; Ozurdex; macular edema; Avastin; bevacizumab; dexamethasone; resistance; anti-VEGF; SECONDARY; THERAPY; AVASTIN; EYES;

D O I：

10.1097/IAE.0b013e31827c53a0

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To test the efficacy of an intravitreal dexamethasone implant in patients with recalcitrant macular edema secondary to retinal vein occlusion. Methods: A retrospective chart review was performed for 18 patients with retinal vein occlusion who received multiple bevacizumab intravitreal injections before treatment with an intravitreal dexamethasone implant. Results: Two subgroups of bevacizumab-resistant patients were identified. Both subgroups responded to subsequent treatment with an intravitreal dexamethasone implant with an average reduction in central foveal thickness of 146.8 +/- 33.65 mu m. A visual acuity improvement of 0.26 +/- 0.07 (logarithm of minimal angle of resolution) was also noted. Intraocular pressure increased by an average of 3.33 +/- 0.66 mmHg and was managed by 1.0 +/- 0.5 topical drops. Conclusion: A subset of patients do not have resolution of macular edema after treatment with intravitreal bevacizumab. Such patients may respond to treatment with an intravitreal dexamethasone implant.

引用

页码：1227 / 1231

页数：5

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