Cerebrovascular Reactivity to Carbon Dioxide in Alzheimer's Disease

被引：109

作者：

Glodzik, Lidia ^{[1
,2
]}

Randall, Catherine ^{[1
]}

Rusinek, Henry ^{[2
]}

de Leon, Mony J. ^{[1
]}

机构：

[1] NYU, Sch Med, Ctr Brain Hlth, Dept Psychiat, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Radiol, New York, NY 10016 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2013年 / 35卷 / 03期

关键词：

Alzheimer's disease; carbon dioxide; cognitive impairment; vascular; vasoreactivity; CEREBRAL-BLOOD-FLOW; VASCULAR RISK-FACTORS; COGNITIVE PERFORMANCE; AMYLOID ANGIOPATHY; NEURONS PROJECT; NITRIC-OXIDE; BRAIN; DEMENTIA; VASOREACTIVITY; ACETAZOLAMIDE;

D O I：

10.3233/JAD-122011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

There is growing evidence that cerebrovascular reactivity to carbon dioxide (CVRCO2) is impaired in Alzheimer's disease (AD). Preclinical and animal studies suggest chronic hypercontractility in brain vessels in AD. We review (a) preclinical studies of mechanisms for impaired CVRCO2 in AD; (b) clinical studies of cerebrovascular function in subjects with AD dementia, mild cognitive impairment (MCI), and normal cognition. Although results of clinical studies are inconclusive, an increasing number of reports reveal an impairment of vascular reactivity to carbon dioxide in subjects with AD, and possibly also in MCI. Thus, CVRCO2 may be an attractive means to detect an early vascular dysfunction in subjects at risk.

引用

页码：427 / 440

页数：14

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