New tricks for old dogmas: Optogenetic and designer receptor insights for Parkinson's disease

被引：24
作者：
Vazey, Elena M. [1 ]
Aston-Jones, Gary [1 ]
机构：
[1] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA
来源：
BRAIN RESEARCH | 2013年 / 1511卷
关键词：
Optogenetic; DREADD; Parkinson's disease; Basal ganglia; Non-motor; Norepinephrine; Dopamine; Striatum; PROTEIN-COUPLED RECEPTORS; TRANSGENIC MICE; LOCUS-COERULEUS; COGNITIVE IMPAIRMENT; NEURAL CIRCUITRY; GENE-THERAPY; ASTROCYTES; NEURONS; BRAIN; INHIBITION;
D O I：
10.1016/j.brainres.2013.01.021
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Optogenetics and novel designer receptors have revolutionized the way neuroscientists can interrogate neural circuits. These new tools are being rapidly applied to many facets of neuroscience including the study of Parkinson's disease circuitry and therapies. This review highlights how optogenetics and designer receptors can be applied in the study of Parkinsonian dysfunction to understand the mechanisms behind motor and non-motor symptoms. We discuss how these tools have recently advanced our understanding of basal ganglia function and outline how they can be applied in future to refine existing treatments and generate novel therapeutic strategies for Parkinson's disease. This article is part of a Special Issue entitled Optogenetics (7th BRES) (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：153 / 163
页数：11
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