B cell-targeted therapy with rituximab and autoimmune neuromuscular disorders

被引：16
作者：
Stuegen, Joerg-Patrick [1 ]
机构：
[1] Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York Presbyterian Hosp, New York, NY 10065 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2008年 / 204卷 / 1-2期
关键词：
B cell depletion; Rituximab; Autoimmune polyneuropathy; Myasthenia gravis; Inflammatory myopathy;
D O I：
10.1016/j.jneuroim.2008.07.019
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
B lymphocytes play a central role in the pathogenesis of autoimmunity, so that B cell suppression is considered a potential treatment option for immune-mediated diseases. Rituximab, a chimeric anti-human CD20 antibody, is the only anti-B cell biological agent presently under study for the treatment of autoimmune neuromuscular diseases. Isolated case histories and series, pilot and retrospective studies report on the experimental administration of rituximab as treatment of a variety of immune-mediated neuropathy syndromes, treatment-refractory myasthenia gravis and inflammatory myopathies. Rituximab was used as monotherapy or in combination with other types of immunomodulation, and was well tolerated. The mechanism whereby B cell depletion shows benefit is uncertain and may vary depending on the inherent differences in the pathogenesis of various autoimmune neuromuscular disorders. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：1 / 12
页数：12
相关论文
共 159 条
[51]   ATAXIC SENSORY NEUROPATHY AND DORSAL-ROOT GANGLIONITIS ASSOCIATED WITH SJOGRENS-SYNDROME [J].
GRIFFIN, JW ;
CORNBLATH, DR ;
ALEXANDER, E ;
CAMPBELL, J ;
LOW, PA ;
BIRD, S ;
FELDMAN, EL .
ANNALS OF NEUROLOGY, 1990, 27 (03) :304-315
[52]   Successful treatment of musk antibody-positive myasthenia gravis with rituximab [J].
Hain, B ;
Jordan, K ;
Deschauer, M ;
Zierz, S .
MUSCLE & NERVE, 2006, 33 (04) :575-580
[53]  
HAUSER S, 2007, AM AC NEUR 59 ANN M
[54]   ANTI-GM(1)/GD(1B) M-PROTEINS DAMAGE HUMAN SPINAL-CORD NEURONS COCULTURED WITH MUSCLE [J].
HEIMANPATTERSON, T ;
KRUPA, T ;
THOMPSON, P ;
NOBILEORAZIO, E ;
TAHMOUSH, AJ ;
SHY, ME .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1993, 120 (01) :38-45
[55]   Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies [J].
Hoch, W ;
McConville, J ;
Helms, S ;
Newsom-Davis, J ;
Melms, A ;
Vincent, A .
NATURE MEDICINE, 2001, 7 (03) :365-368
[56]   ANTI-GM(1) ANTIBODIES AND IMPAIRED BLOOD-NERVE BARRIER MAY INTERFERE WITH REMYELINATION IN MULTIFOCAL MOTOR NEUROPATHY [J].
KAJI, R ;
HIROTA, N ;
OKA, N ;
KOHARA, N ;
WATANABE, T ;
NISHIO, T ;
KIMURA, J .
MUSCLE & NERVE, 1994, 17 (01) :108-110
[57]   PATHOLOGICAL FINDINGS AT THE SITE OF CONDUCTION BLOCK IN MULTIFOCAL MOTOR NEUROPATHY [J].
KAJI, R ;
OKA, N ;
TSUJI, T ;
MEZAKI, T ;
NISHIO, T ;
AKIGUCHI, I ;
KIMURA, J .
ANNALS OF NEUROLOGY, 1993, 33 (02) :152-158
[58]   Anti-signal recognition particle autoantibody in patients with and patients without idiopathic inflammatory myopathy [J].
Kao, AH ;
Lacomis, D ;
Lucas, M ;
Fertig, N ;
Oddis, CV .
ARTHRITIS AND RHEUMATISM, 2004, 50 (01) :209-215
[59]   INVITED REVIEW - PERIPHERAL NEUROPATHY IN SJOGREN SYNDROME [J].
KAPLAN, JG ;
ROSENBERG, R ;
REINITZ, E ;
BUCHBINDER, S ;
SCHAUMBURG, HH .
MUSCLE & NERVE, 1990, 13 (07) :570-579
[60]   Advances in understanding and treatment of immune-mediated disorders of the peripheral nervous system [J].
Kieseier, BC ;
Kiefer, R ;
Gold, R ;
Hemmer, B ;
Willison, HJ ;
Hartung, HP .
MUSCLE & NERVE, 2004, 30 (02) :131-156
12345678910