Association of Angiotensin Converting Enzyme (Insertion/Deletion) Gene Polymorphism with Essential Hypertension in Northern Indian Subjects

被引:18
作者
Srivastava, Kamna [1 ]
Sundriyal, Ruchi [1 ]
Meena, Prakash C. [1 ]
Bhatia, Jagriti [2 ]
Narang, Rajiv [3 ]
Saluja, Daman [1 ]
机构
[1] Univ Delhi, Dr BR Ambedkar Ctr Biomed Res, Delhi 110007, India
[2] All India Inst Med Sci, Dept Pharmacol, New Delhi, India
[3] All India Inst Med Sci, Dept Cardiol, New Delhi, India
关键词
DELETION POLYMORPHISM; DISEASE; RISK; POPULATION; MEN; CAD;
D O I
10.1089/gtmb.2011.0155
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Objective: Essential hypertension is a multifactorial disease in which genetic and environmental factors play an important role. The renin-angiotensin system (RAS) is known to play a critical role in the homeostasis of blood pressure. Angiotensin-I converting enzyme (ACE) is a significant component of RAS, and an insertion/deletion (I/D) polymorphism in its gene has been implicated in predisposition to hypertension. The purpose of the current study is to investigate the association of I/D polymorphism of the ACE gene with essential hypertension in northern Indians. Method: Two hundred twenty-two patients with essential hypertension and 252 controls were recruited for the study. DNA samples were isolated from peripheral blood by using a kit. Polymerase chain reaction was used for genotyping. Result: All the genotypes and allele distribution in study subjects were in the Hardy-Weinberg equilibrium. There was a significant difference in the distribution of DD, II, and ID genotypes of ACE polymorphism in patients and controls. In the subjects having an I allele, the odds ratio is 2.08 [1.6-2.58] at 95% confidence interval, thus suggesting an association of ACE I/D gene polymorphism with essential hypertension. Conclusion: Our findings suggest that the I allele of ACE I/D polymorphism is associated with essential hypertension in our population.
引用
收藏
页码:174 / 177
页数:4
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