Electroacupuncture reduces Aβ production and BACE1 expression in SAMP8 mice

被引：14

作者：

Dong, Wei-Guo ^{[1
]}

Wang, Feng ^{[1
]}

Chen, Ye ^{[1
]}

Zheng, Xue-Hua ^{[1
]}

Xie, Yong-Cai ^{[1
]}

Guo, Wan-Qing ^{[2
]}

Shi, Hong ^{[1
]}

机构：

[1] Fujian Univ Tradit Chinese Med, Dept Integrated Tradit Chinese & Western Med, Fuzhou 350122, Fujian, Peoples R China

[2] Third Peoples Hosp Fujian Prov, Fuzhou, Peoples R China

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2015年 / 7卷

基金：

中国国家自然科学基金;

关键词：

Alzheimer's disease; electroacupuncture; memory impairment; BACE1; amyloid-beta; SENESCENCE-ACCELERATED MOUSE; IMPROVES COGNITIVE DEFICITS; MESSENGER-RNA EXPRESSION; APP/PS1 TRANSGENIC MICE; ALZHEIMERS-DISEASE; AMYLOID-BETA; SECRETASE BACE1; CATHEPSIN-B; MODEL; APP;

D O I：

10.3389/fnagi.2015.00148

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Electroacupuncture (EA) has been reported to have beneficial effects on Alzheimer's disease (AD). BACE1 (beta-site amyloid precursor protein-cleaving enzyme 1) is involved in the abnormal production of amyloid-beta plague (A beta), a hallmark of AD pathophysiology. Thus, the present study investigated the effects of EA on memory impairment, A beta production, and BACE1 expression in senescence-accelerated mouse prone 8 (SAMP8) mice. We found that EA improved spatial learning and memory impairment of SAMP8 mice. Furthermore, EA attenuated A beta production and repressed the expression of BACE1 in the hippocampus of SAMP8 mice. Taken together, our results suggest that EA could have a potential therapeutic application in AD and that BACE1 may be an important target of EA in the treatment of AD.

引用

页数：8

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