Preparation of 5-substituted 1H-tetrazoles from nitriles in water

被引：975
作者：
Demko, ZP
Sharpless, KB
机构：
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2001年 / 66卷 / 24期
关键词：
D O I：
10.1021/jo010635w
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The addition of sodium azide to nitriles to give 1H-tetrazoles is shown to proceed readily in water with zinc salts as catalysts. The scope of the reaction is quite broad; a variety of aromatic nitriles, activated and unactivated alkyl nitriles, substituted vinyl nitriles, thiocyanates, and cyanamides have all been shown to be viable substrates for this reaction.
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页码：7945 / 7950
页数：6
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