Homeobox transcription factor Pitx2: The rise of an asymmetry gene in cardiogenesis and arrhythmogenesis

被引：39
作者：
Franco, Diego [1 ]
Christoffels, Vincent M. [2 ]
Campione, Marina [3 ]
机构：
[1] Univ Jaen, Dept Expt Biol B3 362, Jaen 23071, Spain
[2] Univ Amsterdam, Acad Med Ctr, Heart Failure Res Ctr, NL-1105 AZ Amsterdam, Netherlands
[3] Univ Padua, Inst Neurosci, CNR, Dept Biomed Sci, Padua, Italy
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 2014年 / 24卷 / 01期
关键词：
ATRIAL-FIBRILLATION RECURRENCE; AXENFELD-RIEGER SYNDROME; 2ND HEART FIELDS; OUTFLOW TRACT; CHAMBER FORMATION; VERTEBRATE HEART; CHROMOSOME; 4Q25; CARDIAC LINEAGE; AORTIC-ARCH; BODY-WALL;
D O I：
10.1016/j.tcm.2013.06.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The homeobox transcription factor Pitx2 displays a highly specific expression pattern during embryogenesis. Gain and loss of function experiments have unraveled its pivotal role in left-right signaling. Conditional deletion in mice has demonstrated a complex and intricate role for Pitx2 in distinct aspects of cardiac development and more recently a link to atrial fibrillation has been proposed based on genome-wide association studies. In this review we will revise the role of Pitx2 in the developing heart, starting from the early events of left-right determination followed by its role in cardiac morphogenesis and ending with its role in cardiac arrhythmogenesis. (C) 2013 Elsevier Inc. All rights reserved.
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收藏
页码：23 / 31
页数：9
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