Development of novel, water-soluble inhibitors of poly(adenosine 5′-diphosphate ribose) synthetase activity for use in shock and ischemia-reperfusion injury

被引:9
作者
Thiemermann, C [1 ]
机构
[1] St Bartholomews & Royal London Sch Med & Dent, William Harvey Res Inst, Dept Expt Med & Nephrol, London, England
关键词
poly(adenosine 5 '-diphosphate ribose) synthetase; nicotinamide adenine dinucleotide; endotoxic shock; hemorrhagic shock; ischemia-reperfusion injury;
D O I
10.1097/00003246-200205000-00038
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
引用
收藏
页码:1163 / 1165
页数:3
相关论文
共 13 条
[1]   PARP-2, a novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase [J].
Amé, JC ;
Rolli, V ;
Schreiber, V ;
Niedergang, C ;
Apiou, F ;
Decker, P ;
Muller, S ;
Hoger, T ;
Murcia, JMD ;
de Murcia, G .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (25) :17860-17868
[2]   Dual inhibitory effects of dimethyl sulfoxide on poly(ADP-ribose) synthetase [J].
Banasik, M ;
Ueda, K .
JOURNAL OF ENZYME INHIBITION, 1999, 14 (03) :239-250
[3]   Reduction of myocardial reperfusion injury by an inhibitor of poly (ADP-ribose) synthetase in the pig [J].
Bowes, J ;
Ruetten, H ;
Martorana, PA ;
Stockhausen, H ;
Thiemermann, C .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1998, 359 (2-3) :143-150
[4]   Protective effect of a novel, potent inhibitor of poly(adenosine 5′-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis [J].
Goldfarb, RD ;
Marton, A ;
Szabó, É ;
Virág, L ;
Salzman, AL ;
Glock, D ;
Akhter, I ;
McCarthy, R ;
Parrillo, JE ;
Szabó, C .
CRITICAL CARE MEDICINE, 2002, 30 (05) :974-980
[5]   Novel phenanthridinone inhibitors of poly(adenosine 5′-diphosphateribose) synthetase:: Potent cytoprotective and antishock agents [J].
Jagtap, P ;
Soriano, FG ;
Virág, L ;
Liaudet, L ;
Mabley, J ;
Szabó, É ;
Haskó, G ;
Marton, A ;
Lorigados, CB ;
Gallyas, F ;
Sümegi, B ;
Hoyt, DG ;
Baloglu, E ;
VanDuzer, J ;
Salzman, AL ;
Southan, GJ ;
Szabó, C .
CRITICAL CARE MEDICINE, 2002, 30 (05) :1071-1082
[6]   Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock [J].
McDonald, MC ;
Mota-Filipe, H ;
Wright, JA ;
Abdelrahman, M ;
Threadgill, MD ;
Thompson, AS ;
Thiemermann, C .
BRITISH JOURNAL OF PHARMACOLOGY, 2000, 130 (04) :843-850
[7]   Poly (ADP-ribose) polymerase, nitric oxide and cell death [J].
Pieper, AA ;
Verma, A ;
Zhang, J ;
Snyder, SH .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1999, 20 (04) :171-181
[8]   HYDROGEN PEROXIDE-INDUCED INJURY OF CELLS AND ITS PREVENTION BY INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE [J].
SCHRAUFSTATTER, IU ;
HYSLOP, PA ;
HINSHAW, DB ;
SPRAGG, RG ;
SKLAR, LA ;
COCHRANE, CG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (13) :4908-4912
[9]   DNA strand breakage, activation of poly(ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite [J].
Szabo, C ;
Zingarelli, B ;
OConnor, M ;
Salzman, AL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (05) :1753-1758
[10]  
Szabo C., 2000, CELL DEATH ROLE PARP