Carborane-Based Carbonic Anhydrase Inhibitors

被引：84

作者：

Brynda, Jiri ^{[1
,2
]}

Mader, Pavel ^{[1
]}

Sicha, Vaclav ^{[3
]}

Fabry, Milan ^{[1
]}

Poncova, Kristyna ^{[2
]}

Bakardiev, Mario ^{[3
]}

Gruener, Bohumir ^{[3
]}

Cigler, Petr ^{[2
]}

Rezacova, Pavlina ^{[1
,2
]}

机构：

[1] Acad Sci Czech Republ, Inst Mol Genet, Vvi, Prague 14220 4, Czech Republic

[2] Acad Sci Czech Republ, Inst Organ Chem & Biochem, Vvi, Prague 16610 6, Czech Republic

[3] Acad Sci Czech Republ, Inst Inorgan Chem, Vvi, Prague 25068, Czech Republic

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 51期

关键词：

carbonic anhydrases; carboranes; drug discovery; inhibitors; structure elucidation; DRUG DISCOVERY; BORON; PHARMACOPHORES;

D O I：

10.1002/anie.201307583

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

CA inhibitors: Human carbonic anhydrases (CAs) are diagnostic and therapeutic targets. Various carborane cages are shown to act as active-site-directed inhibitors, and substitution with a sulfamide group and other substituents leads to compounds with high selectivity towards the cancer-specific isozyme IX. Crystal structures of the carboranes in the active site provide information that can be applied to the structure-based design of specific inhibitors. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：13760 / 13763

页数：4

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