Widespread Changes in Dendritic Spines in a Model of Alzheimer's Disease

被引：104

作者：

Knafo, S. ^{[1
]}

Alonso-Nanclares, L. ^{[1
]}

Gonzalez-Soriano, J. ^{[2
]}

Merino-Serrais, P. ^{[1
]}

Fernaud-Espinosa, I. ^{[1
]}

Ferrer, I. ^{[3
]}

DeFelipe, J. ^{[1
]}

机构：

[1] CSIC, Inst Cajal, E-28002 Madrid, Spain

[2] Univ Complutense, Fac Vet Med, Dept Anat, E-28040 Madrid, Spain

[3] Univ Barcelona, Inst Neuropatol, IDIBELL Hosp Univ Bellvitge, Hospitalet LLobregat, Barcelona 08907, Spain

来源：

CEREBRAL CORTEX | 2009年 / 19卷 / 03期

关键词：

Alzheimer's disease; confocal microscopy; dementia; dentate gyrus; transgenic mice; AMYLOID PRECURSOR PROTEIN; LONG-TERM POTENTIATION; CEREBRAL-CORTEX; SENILE PLAQUES; ADULT CORTEX; SYNAPSE LOSS; MOUSE MODEL; IN-VIVO; MICE; PLASTICITY;

D O I：

10.1093/cercor/bhn111

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The mechanism by which dementia occurs in patients with Alzheimer's disease (AD) is not known. We assessed changes in hippocampal dendritic spines of APP/PS1 transgenic mice that accumulate amyloid beta throughout the brain. Three-dimensional analysis of 21 507 dendritic spines in the dentate gyrus, a region crucial for learning and memory, revealed a substantial decrease in the frequency of large spines in plaque-free regions of APP/PS1 mice. Plaque-related dendrites also show striking alterations in spine density and morphology. However, plaques occupy only 3.9% of the molecular layer volume. Because large spines are considered to be the physical traces of long-term memory, widespread decrease in the frequency of large spines likely contributes to the cognitive impairments observed in this AD model.

引用

页码：586 / 592

页数：7

共 41 条

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