Opening the lid on piano-stool complexes: An account of ruthenium(II)-arene complexes with medicinal applications

被引：246

作者：

Nazarov, Alexey A. ^{[1
]}

Hartinger, Christian G. ^{[2
]}

Dyson, Paul J. ^{[3
]}

机构：

[1] Moscow MV Lomonosov State Univ, Dept Organ Chem, Moscow 119991, Russia

[2] Univ Auckland, Sch Chem Sci, Auckland 1142, New Zealand

[3] Ecole Polytech Fed Lausanne, EPFL BCH, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2014年 / 751卷

基金：

俄罗斯基础研究基金会;

关键词：

Bioorganometallic chemistry; Piano-stool compounds; Ruthenium arene complexes; Anticancer drugs; Antimetastasis drugs; Targeted chemotherapy; HALF-SANDWICH COMPLEXES; ORGANOMETALLIC RUTHENIUM COMPLEXES; ESTROGEN-RECEPTOR MODULATORS; VITRO ANTICANCER ACTIVITY; IN-VITRO; BIOORGANOMETALLIC CHEMISTRY; ARENE COMPLEXES; TRANSFER HYDROGENATION; PHOTODYNAMIC THERAPY; METAL-COMPLEXES;

D O I：

10.1016/j.jorganchem.2013.09.016

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Interest in the medicinal properties of ruthenium(II)-arene compounds has grown rapidly over the last decade. In this account we describe the origins of the field and subsequently highlight developments in the field, including the design of compounds that inhibit enzymes, the application of multinuclear systems to act as drug delivery vehicles, and the development of bioanalytical and biophysical methods to help elucidate the mechanisms by which these compounds function. The conducive properties and reasons for the rapid growth in interest in these and related compounds for their medicinal applications, especially in the treatment of solid tumours, are identified. (C) 2013 Elsevier B. V. All rights reserved.

引用

页码：251 / 260

页数：10

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