4-Oxo-N-phenyl-4H-chromene-2-carboxamide and of a new polymorph of 7-methoxy-4-oxo-N-p-tolyl-4H-chromene-2-carboxamide and its hemihydrate

被引：2

作者：

Reis, Joana ^{[1
]}

Gaspar, Alexandra ^{[1
]}

Borges, Fernanda ^{[1
]}

Gomes, Ligia R. ^{[2
,3
]}

Low, John Nicolson ^{[4
]}

机构：

[1] Univ Porto, Fac Ciencias, CIQ Dept Quim & Bioquim, P-4169007 Oporto, Portugal

[2] Univ Fernando Pessoa, Escola Super Saude UFP, CIAGEB Fac Ciencias Saude, P-4200150 Oporto, Portugal

[3] Univ Porto, Fac Ciencias, Dept Quim & Bioquim, REQUIMTE, P-4169007 Oporto, Portugal

[4] Univ Aberdeen, Dept Chem, Old Aberdeen AB24 3UE, Scotland

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 2013年 / 69卷

关键词：

crystal structure; drug design; chromones; conformation; supramolecular structure;

D O I：

10.1107/S0108270113029727

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

4-Oxo-N-phenyl-4H-chromene-2-carboxamide, C16H11NO3, crystallizes in the space group P2(1)/n and its derivative 7-methoxy-4-oxo-N-p-tolyl-4H-chromene-2-carboxamide, C18H15NO4, forms two polymorphs which crystallize in the space groups P2(1)/c and P (1) over bar. The structures have an anti-rotamer conformation about the C-N bond; however, the amide O atom can be either trans-or cis-related to the O atom of the pyran ring. The latter compound also crystallizes as a hemihydrate, C18H15NO4 center dot 0.5H(2)O, in the space group C2/c. This compound has a similar structure to that of the unsolvated compound.

引用

页码：1527 / +

页数：20

共 15 条

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