Association study of FGF18 with developmental dyslexia in Chinese population

被引：6

作者：

Chen, Huan ^{[1
,4
]}

Zhou, Yuxi ^{[5
,6
]}

Ge, Zeng ^{[5
,6
]}

Li, Qian ^{[5
,6
]}

Sun, Qinsheng ^{[2
]}

Zheng, Liyuan ^{[5
,6
]}

Lv, Hong ^{[5
,6
]}

Tan, Li-Hai ^{[1
,3
]}

Sun, Yimin ^{[2
,5
,6
,7
]}

机构：

[1] Tsinghua Univ, Shenzhen Inst Neurosci, Ctr Neurogenet, Shenzhen, Peoples R China

[2] Tsinghua Univ, Grad Sch Shenzhen, State Key Lab Breeding Base, Shenzhen Key Lab Chem Biol, Shenzhen, Peoples R China

[3] Shenzhen Univ, Hlth Sci Ctr, Sch Biomed Engn, Shenzhen, Peoples R China

[4] Beijing Inst Radiat Med, Beijing Proteome Res Ctr, State Key Lab Prote, Beijing, Peoples R China

[5] CapitalBio EHlth Sci & Technol Co Ltd, Beijing, Peoples R China

[6] Natl Engn Res Ctr Beijing Biochip Technol, Beijing, Peoples R China

[7] Tsinghua Univ, Sch Med, Med Syst Biol Res Ctr, Dept Biomed Engn, Beijing, Peoples R China

来源：

PSYCHIATRIC GENETICS | 2018年 / 28卷 / 01期

关键词：

developmental dyslexia; fibroblast growth factors; genetic susceptibility; GENOME-WIDE ASSOCIATION; CANDIDATE GENES; READING-DISABILITY; LANGUAGE; KIAA0319; CORTEX; DCDC2; VARIANTS; TRAITS; BRAIN;

D O I：

10.1097/YPG.0000000000000187

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Developmental dyslexia (DD) is a neurobiological disorder featured by reading disabilities. In recent years, genome-wide approaches provided new perspectives to discover novel candidate genes of DD. In a previous study, rs9313548 located downstream of FGF18 showed borderline genome-wide significant association with DD. Herein, we selected rs9313548 and 11 independent tag single nucleotide polymorphisms covering gene region of FGF18 to perform association analysis with DD among 978 Chinese dyslexic cases and 998 controls recruited from elementary schools. However, we did not observe any single nucleotide polymorphism exceeding significant threshold. Our preliminary results suggested that FGF18 might not be a susceptibility gene for DD in Chinese population.

引用

页码：8 / 11

页数：4

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