Regulation of Bacterial Metabolism by Small RNAs Using Diverse Mechanisms

被引:77
作者
Bobrovskyy, Maksym [1 ]
Vanderpool, Carin K. [1 ]
机构
[1] Univ Illinois, Dept Microbiol, Urbana, IL 61801 USA
来源
ANNUAL REVIEW OF GENETICS, VOL 47 | 2013年 / 47卷
关键词
Hfq; RNase E; riboswitch; SgrS; Spot; 42; CRC GLOBAL REGULATOR; CARBON CATABOLITE REPRESSION; SM-LIKE PROTEIN; CARBOHYDRATE PHOSPHOTRANSFERASE SYSTEMS; PSEUDOMONAS-FLUORESCENS CHA0; ESCHERICHIA-COLI MUTANTS; BINDING SMALL RNA; MESSENGER-RNA; BACILLUS-SUBTILIS; SOLUBLE-RNA;
D O I
10.1146/annurev-genet-111212-133445
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Bacteria live in many dynamic environments with alternating cycles of feast or famine that have resulted in the evolution of mechanisms to quickly alter their metabolic capabilities. Such alterations often involve complex regulatory networks that modulate expression of genes involved in nutrient uptake and metabolism. A great number of protein regulators of metabolism have been characterized in depth. However, our ever-increasing understanding of the roles played by RNA regulators has revealed far greater complexity to regulation of metabolism in bacteria. Here, we review the mechanisms and functions of selected bacterial RNA regulators and discuss their importance in modulating nutrient uptake as well as primary and secondary metabolic pathways.
引用
收藏
页码:209 / 232
页数:24
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