Fecal microbiota transplantation in non-communicable diseases: Recent advances and protocols

被引:24
作者
Hamamah, Sevag [1 ]
Gheorghita, Roxana [2 ,3 ]
Lobiuc, Andrei [2 ]
Sirbu, Ioan-Ovidiu [3 ,4 ]
Covasa, Mihai [1 ,2 ]
机构
[1] Western Univ Hlth Sci, Coll Osteopath Med, Dept Basic Med Sci, Pomona, CA 91766 USA
[2] Univ Suceava, Coll Med & Biol Sci, Dept Med & Biomed Sci, Suceava, Romania
[3] Victor Babes Univ Med & Pharm Timisoara, Dept Biochem, Timisoara, Romania
[4] Victor Babes Univ Med & Pharm Timisoara, Ctr Complex Network Sci, Timisoara, Romania
关键词
microbiota transplant; obesity; metabolic disease; inflammatory bowel disease; irritable bowel syndrome; cirrhosis; cancer; FMT protocol; CLOSTRIDIUM-DIFFICILE INFECTION; GUT MICROBIOTA; METABOLIC SYNDROME; ULCERATIVE-COLITIS; INTESTINAL MICROBIOTA; COLORECTAL-CANCER; DONOR FECES; RECURRENT; FROZEN; EFFICACY;
D O I
10.3389/fmed.2022.1060581
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Fecal microbiota transplant (FMT) is a therapeutic method that aims to restore normal gut microbial composition in recipients. Currently, FMT is approved in the USA to treat recurrent and refractory Clostridioides difficile infection and has been shown to have great efficacy. As such, significant research has been directed toward understanding the potential role of FMT in other conditions associated with gut microbiota dysbiosis such as obesity, type 2 diabetes mellitus, metabolic syndrome, neuropsychiatric disorders, inflammatory bowel disease, irritable bowel syndrome, decompensated cirrhosis, cancers and graft-versus-host disease. This review examines current updates and efficacy of FMT in treating conditions other than Clostridioides difficile infection. Further, protocols for administration of FMT are also discussed including storage of fecal samples in stool banks, inclusion/exclusion criteria for donors, fecal sample preparation and methods of treatment administration. Overall, understanding the mechanisms by which FMT can manipulate gut microbiota to provide therapeutic benefit as well as identifying potential adverse effects is an important step in clarifying its long-term safety and efficacy in treating multiple conditions in the future.
引用
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页数:25
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