Low Prevalence of Cfr-Mediated Linezolid Resistance among Methicillin-Resistant Staphylococcus aureus in a Spanish Hospital: Case Report on Linezolid Resistance Acquired during Linezolid Therapy

被引：18
作者：
Sierra, Josep M. [1 ]
Camoez, Mariana [1 ]
Tubau, Fe [1 ]
Gasch, Oriol [2 ]
Pujol, Miquel [2 ]
Martin, Rogelio [1 ]
Angeles Dominguez, M. [1 ]
机构：
[1] Univ Barcelona, Dept Microbiol, Hosp Univ Bellvitge IDIBELL, Dept Pathol & Expt Therapeut, Barcelona, Spain
[2] Univ Barcelona, Hosp Univ Bellvitge IDIBELL, Dept Pathol & Expt Therapeut, Dept Infect Dis, Barcelona, Spain
来源：
PLOS ONE | 2013年 / 8卷 / 03期
关键词：
GENE; MECHANISM;
D O I：
10.1371/journal.pone.0059215
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Linezolid is an effective antimicrobial agent to treat methicillin-resistant Staphylococcus aureus (MRSA). Resistance to linezolid due to the cfr gene is described worldwide. The present study aimed to analyze the prevalence of the cfr-mediated linezolid resistance among MRSA clinical isolates in our area. A very low prevalence of cfr mediated linezolid resistance was found: only one bacteremic isolate out of 2 215 screened isolates. The only linezolid resistant isolate arose in a patient, previously colonized by MRSA, following linezolid therapy. Despite the low rate of resistance in our area, ongoing surveillance is advisable to avoid the spread of linezolid resistance.
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