Novel Insights into the Pharmacology of Flavonoids

被引:203
作者
Romano, Barbara [1 ]
Pagano, Ester [1 ]
Montanaro, Vittorino [2 ]
Fortunato, Alfonso L. [1 ]
Milic, Natasa [3 ]
Borrelli, Francesca [1 ]
机构
[1] Univ Naples Federico II, Dept Urol, I-80131 Naples, Italy
[2] Univ Naples Federico II, Dept Pharm, I-80131 Naples, Italy
[3] Univ Novi Sad, Fac Med, Dept Pharm, Novi Sad 21000, Serbia
关键词
antioxidant; apoptosis; cancer; flavonoids; isoflavonoids; phytoestrogens; quercetin; silybin; WORT HYPERICUM-PERFORATUM; CENTRAL-NERVOUS-SYSTEM; COLON-CANCER CELLS; AIRWAY INFLAMMATION; ANTIOXIDANT FLAVONOIDS; GENE-EXPRESSION; P-GLYCOPROTEIN; QUERCETIN; EXTRACT; RAT;
D O I
10.1002/ptr.5023
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Flavonoids are widely distributed secondary metabolites and currently consumed in large amounts in the daily diet. In this article, some of the most recent developments in flavonoid - and related polyphenolic compounds - pharmacology are discussed, with particular emphasis on very recent data, most of which are published in Phytotherapy Research, which highlight new aspects in flavonoid anti-inflammatory, antilipidemic, antihyperglycemic, antiviral, hepatoprotective, gastric antiulcer, cardioprotective, neuroprotective, antioxidant and anticancer actions. These updated data confirm the well-established diverse beneficial pharmacological actions and might support the perspective for a therapeutic use. Copyright (c) 2013 John Wiley & Sons, Ltd.
引用
收藏
页码:1588 / 1596
页数:9
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