SARS-CoV-2 infection: The role of cytokines in COVID-19 disease

被引：747
|
作者：
Costela-Ruiz, Victor J. [1 ,2 ]
Illescas-Montes, Rebeca [1 ,2 ]
Puerta-Puerta, Jose M. [3 ]
Ruiz, Concepcion [1 ,2 ,4 ]
Melguizo-Rodriguez, Lucia [1 ,2 ]
机构：
[1] Univ Granada, Fac Hlth Sci, Dept Nursing, Biomed Grp BIO277, Avda Ilustrac 60, Granada 18016, Spain
[2] Ibs Granada, Inst Biosanit Res, C Doctor Asspitarte 4,4a Planta, Granada 18012, Spain
[3] Univ Hosp Virgen de las Nieves, Hematol & Hemotherapy Unit, Granada, Spain
[4] Univ Granada, Inst Neurosci, Ctr Invest Biomed CIBM, Parque Tecnol Salud PTS Avda Conocimiento S-N, Granada 18016, Spain
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2020年 / 54卷
关键词：
COVID-19; SARS-CoV-2; Chemokines; Growth factors; Cytokine storm; COLONY-STIMULATING FACTOR; MESSENGER-RNA EXPRESSION; SARS-CORONAVIRUS; GM-CSF; INTERFERON-GAMMA; DENDRITIC CELLS; INTERLEUKIN-3; IL-3; FETAL MONOCYTES; VIRAL-INFECTION; GROWTH-FACTOR;
D O I：
10.1016/j.cytogfr.2020.06.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-gamma, and TNF-alpha, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients with COVID-19 who require admission to an intensive care unit. Data on the implication of cytokines in this disease and their effect on outcomes will support the design of more effective approaches to the management of COVID-19.
引用
收藏
页码：62 / 75
页数：14
相关论文
共 50 条
  • [41] SARS-CoV-2 and COVID-19 for the ophthalmologist
    Brandao-de-Resende, Camilo
    Diniz-Filho, Alberto
    de Almeida Brito, Fabiano
    Vasconcelos-Santos, Daniel Vitor
    CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2021, 49 (01) : 70 - 80
  • [42] Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity
    Tangye, Stuart G.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2023, 151 (04) : 818 - 831
  • [43] The four horsemen of a viral Apocalypse: The pathogenesis of SARS-CoV-2 infection (COVID-19)
    Domingo, Pere
    Mur, Isabel
    Pomar, Virginia
    Corominas, Hector
    Casademont, Jordi
    Benito, Natividad de
    EBIOMEDICINE, 2020, 58
  • [44] Pharmacological options in treating SARS-CoV-2 infection/COVID-19
    Fabian Akos
    Laszlo Istvan
    Juhasz Marianna
    Berhes Mariann
    Vegh Tamas
    Koszta Gyorgy
    Molnar Csilla
    Fulesdi Bela
    ORVOSI HETILAP, 2020, 161 (17) : 685 - 688
  • [45] Immunological memory to SARS-CoV-2 infection and COVID-19 vaccines
    Sette, Alessandro
    Crotty, Shane
    IMMUNOLOGICAL REVIEWS, 2022, 310 (01) : 27 - 46
  • [46] SARS-CoV-2 outbreak: role of viral proteins and genomic diversity in virus infection and COVID-19 progression
    Hussein, Hosni A. M.
    Thabet, Ali A.
    Wardany, Ahmed A.
    El-Adly, Ahmed M.
    Ali, Mohamed
    Hassan, Mohamed E. A.
    Abdeldayem, Mohamed A. B.
    Mohamed, Abdul-Rahman M. A.
    Sobhy, Ali
    El-Mokhtar, Mohamed A.
    Afifi, Magdy M.
    Fathy, Samah M.
    Sultan, Serageldeen
    VIROLOGY JOURNAL, 2024, 21 (01)
  • [47] COVID-19 Pandemic: Insights into Interactions between SARS-CoV-2 Infection and MAFLD
    Chen, Hanfei
    Chen, Qiang
    INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2022, 18 (12): : 4756 - 4767
  • [48] COVID-19: The Potential Treatment of Pulmonary Fibrosis Associated with SARS-CoV-2 Infection
    Lechowicz, Kacper
    Drozdzal, Sylwester
    Machaj, Filip
    Rosik, Jakub
    Szostak, Bartosz
    Zegan-Baranska, Malgorzata
    Biernawska, Jowita
    Dabrowski, Wojciech
    Rotter, Iwona
    Kotfis, Katarzyna
    JOURNAL OF CLINICAL MEDICINE, 2020, 9 (06) : 1 - 20
  • [49] A case of COVID-19 reinfection in a hemodialysis patient: the role of antibody in SARS-CoV-2 infection
    Hiroko Beppu
    Toshie Ogawa
    Masahiro Ishikane
    Tomoko Kawanishi
    Tatsuya Fukuda
    Lubuna Sato
    Akihiro Matsunaga
    Kenji Maeda
    Daisuke Katagiri
    Yukihito Ishizaka
    Hiroaki Mitsuya
    Norio Ohmagari
    Fumihiko Yasui
    Michinori Kohara
    Kan Kikuchi
    Sachiko Wakai
    CEN Case Reports, 2022, 11 : 422 - 427
  • [50] The Association of Electronic Cigarette Use With SARS-CoV-2 Infection and COVID-19 Disease Severity
    Burnett-Hartman, Andrea N.
    Goldberg Scott, Shauna
    Powers, J. David
    Clennin, Morgan N.
    Lyons, Jason A.
    Gray, Mark
    Feigelson, Heather Spencer
    TOBACCO USE INSIGHTS, 2022, 15
12345