SARS-CoV-2 infection: The role of cytokines in COVID-19 disease

被引：747
|
作者：
Costela-Ruiz, Victor J. [1 ,2 ]
Illescas-Montes, Rebeca [1 ,2 ]
Puerta-Puerta, Jose M. [3 ]
Ruiz, Concepcion [1 ,2 ,4 ]
Melguizo-Rodriguez, Lucia [1 ,2 ]
机构：
[1] Univ Granada, Fac Hlth Sci, Dept Nursing, Biomed Grp BIO277, Avda Ilustrac 60, Granada 18016, Spain
[2] Ibs Granada, Inst Biosanit Res, C Doctor Asspitarte 4,4a Planta, Granada 18012, Spain
[3] Univ Hosp Virgen de las Nieves, Hematol & Hemotherapy Unit, Granada, Spain
[4] Univ Granada, Inst Neurosci, Ctr Invest Biomed CIBM, Parque Tecnol Salud PTS Avda Conocimiento S-N, Granada 18016, Spain
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2020年 / 54卷
关键词：
COVID-19; SARS-CoV-2; Chemokines; Growth factors; Cytokine storm; COLONY-STIMULATING FACTOR; MESSENGER-RNA EXPRESSION; SARS-CORONAVIRUS; GM-CSF; INTERFERON-GAMMA; DENDRITIC CELLS; INTERLEUKIN-3; IL-3; FETAL MONOCYTES; VIRAL-INFECTION; GROWTH-FACTOR;
D O I：
10.1016/j.cytogfr.2020.06.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-gamma, and TNF-alpha, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients with COVID-19 who require admission to an intensive care unit. Data on the implication of cytokines in this disease and their effect on outcomes will support the design of more effective approaches to the management of COVID-19.
引用
收藏
页码：62 / 75
页数：14
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