SARS-CoV-2 infection: The role of cytokines in COVID-19 disease

被引：770

作者：

Costela-Ruiz, Victor J. ^{[1
,2
]}

Illescas-Montes, Rebeca ^{[1
,2
]}

Puerta-Puerta, Jose M. ^{[3
]}

Ruiz, Concepcion ^{[1
,2
,4
]}

Melguizo-Rodriguez, Lucia ^{[1
,2
]}

机构：

[1] Univ Granada, Fac Hlth Sci, Dept Nursing, Biomed Grp BIO277, Avda Ilustrac 60, Granada 18016, Spain

[2] Ibs Granada, Inst Biosanit Res, C Doctor Asspitarte 4,4a Planta, Granada 18012, Spain

[3] Univ Hosp Virgen de las Nieves, Hematol & Hemotherapy Unit, Granada, Spain

[4] Univ Granada, Inst Neurosci, Ctr Invest Biomed CIBM, Parque Tecnol Salud PTS Avda Conocimiento S-N, Granada 18016, Spain

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2020年 / 54卷

关键词：

COVID-19; SARS-CoV-2; Chemokines; Growth factors; Cytokine storm; COLONY-STIMULATING FACTOR; MESSENGER-RNA EXPRESSION; SARS-CORONAVIRUS; GM-CSF; INTERFERON-GAMMA; DENDRITIC CELLS; INTERLEUKIN-3; IL-3; FETAL MONOCYTES; VIRAL-INFECTION; GROWTH-FACTOR;

D O I：

10.1016/j.cytogfr.2020.06.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-gamma, and TNF-alpha, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients with COVID-19 who require admission to an intensive care unit. Data on the implication of cytokines in this disease and their effect on outcomes will support the design of more effective approaches to the management of COVID-19.

引用

页码：62 / 75

页数：14

共 191 条

[11]

[Anonymous], 2020, VADEMECUM CURA PERSO

[12]

[Anonymous], 2017, VIRUSES-BASEL, DOI DOI 10.3390/v9040064

[13]

[Anonymous], 2020, STANFORD MED COVID 1

[14]

[Anonymous], 2020, RARE METALS 0224, DOI DOI 10.1101/2020.02.26

[15]

[Anonymous], 2020, NEW ENGL J MED, DOI DOI 10.1056/NEJMoa2001191

[16] VEGF in Signaling and Disease: Beyond Discovery and Development [J].

Apte, Rajendra S. ;

Chen, Daniel S. ;

Ferrara, Napoleone .

CELL, 2019, 176 (06) :1248-1264

[17] Molecular analysis of the granulocyte colony-stimulating factor receptor [J].

Avalos, BR .

BLOOD, 1996, 88 (03) :761-777

[18] Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis [J].

Bambouskova, Monika ;

Gorvel, Laurent ;

Lampropoulou, Vicky ;

Sergushichev, Alexey ;

Loginicheva, Ekaterina ;

Johnson, Kendall ;

Korenfeld, Daniel ;

Mathyer, Mary Elizabeth ;

Kim, Hyeryun ;

Huang, Li-Hao ;

Duncan, Dustin ;

Bregman, Howard ;

Keskin, Abdurrahman ;

Santeford, Andrea ;

Apte, Rajendra S. ;

Sehgal, Raghav ;

Johnson, Britney ;

Amarasinghe, Gaya K. ;

Soares, Miguel P. ;

Satoh, Takashi ;

Akira, Shizuo ;

Hai, Tsonwin ;

Strong, Cristina de Guzman ;

Auclair, Karine ;

Roddy, Thomas P. ;

Biller, Scott A. ;

Jovanovic, Marko ;

Klechevsky, Eynav ;

Stewart, Kelly M. ;

Randolph, Gwendalyn J. ;

Artyomov, Maxim N. .

NATURE, 2018, 556 (7702) :501-+

[19] Activation of type III nitric oxide synthase in astrocytes following a neurotropic viral infection [J].

Barna, M ;

Komatsu, T ;

Reiss, CS .

VIROLOGY, 1996, 223 (02) :331-343

[20] Cytokine synergy: An underappreciated contributor to innate anti-viral immunity [J].

Bartee, Eric ;

McFadden, Grant .

CYTOKINE, 2013, 63 (03) :237-240

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