SARS-CoV-2 infection: The role of cytokines in COVID-19 disease

被引：747
|
作者：
Costela-Ruiz, Victor J. [1 ,2 ]
Illescas-Montes, Rebeca [1 ,2 ]
Puerta-Puerta, Jose M. [3 ]
Ruiz, Concepcion [1 ,2 ,4 ]
Melguizo-Rodriguez, Lucia [1 ,2 ]
机构：
[1] Univ Granada, Fac Hlth Sci, Dept Nursing, Biomed Grp BIO277, Avda Ilustrac 60, Granada 18016, Spain
[2] Ibs Granada, Inst Biosanit Res, C Doctor Asspitarte 4,4a Planta, Granada 18012, Spain
[3] Univ Hosp Virgen de las Nieves, Hematol & Hemotherapy Unit, Granada, Spain
[4] Univ Granada, Inst Neurosci, Ctr Invest Biomed CIBM, Parque Tecnol Salud PTS Avda Conocimiento S-N, Granada 18016, Spain
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2020年 / 54卷
关键词：
COVID-19; SARS-CoV-2; Chemokines; Growth factors; Cytokine storm; COLONY-STIMULATING FACTOR; MESSENGER-RNA EXPRESSION; SARS-CORONAVIRUS; GM-CSF; INTERFERON-GAMMA; DENDRITIC CELLS; INTERLEUKIN-3; IL-3; FETAL MONOCYTES; VIRAL-INFECTION; GROWTH-FACTOR;
D O I：
10.1016/j.cytogfr.2020.06.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-gamma, and TNF-alpha, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients with COVID-19 who require admission to an intensive care unit. Data on the implication of cytokines in this disease and their effect on outcomes will support the design of more effective approaches to the management of COVID-19.
引用
收藏
页码：62 / 75
页数：14
相关论文
共 50 条
  • [1] Role of Senescence and Aging in SARS-CoV-2 Infection and COVID-19 Disease
    Lynch, Seodhna M.
    Guo, Guangran
    Gibson, David S.
    Bjourson, Anthony J.
    Rai, Taranjit Singh
    CELLS, 2021, 10 (12)
  • [2] ACEing COVID-19 A Role for Angiotensin Axis Inhibition in SARS-CoV-2 Infection?
    Murthy, Venkatesh L.
    Koupenova, Milka
    Shah, Ravi V.
    CIRCULATION RESEARCH, 2020, 126 (12) : 1682 - 1684
  • [3] SARS-CoV-2 Infection and COVID-19 in Children
    Waghmare, Alpana
    Hijano, Diego R.
    CLINICS IN CHEST MEDICINE, 2023, 44 (02) : 359 - 371
  • [4] SARS-CoV-2 Infection and COVID-19 in Children
    Waghmare, Alpana
    Hijano, Diego R.
    RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 2025, 51 (01) : 139 - 156
  • [5] Role of Oxidative Stress on SARS-CoV (SARS) and SARS-CoV-2 (COVID-19) Infection: A Review
    Shanzay Suhail
    Jonathan Zajac
    Carl Fossum
    Harrison Lowater
    Cailin McCracken
    Nathaniel Severson
    Bethany Laatsch
    Alex Narkiewicz-Jodko
    Benjamin Johnson
    Jessica Liebau
    Sudeep Bhattacharyya
    Sanchita Hati
    The Protein Journal, 2020, 39 : 644 - 656
  • [6] Role of Oxidative Stress on SARS-CoV (SARS) and SARS-CoV-2 (COVID-19) Infection: A Review
    Suhail, Shanzay
    Zajac, Jonathan
    Fossum, Carl
    Lowater, Harrison
    McCracken, Cailin
    Severson, Nathaniel
    Laatsch, Bethany
    Narkiewicz-Jodko, Alex
    Johnson, Benjamin
    Liebau, Jessica
    Bhattacharyya, Sudeep
    Hati, Sanchita
    PROTEIN JOURNAL, 2020, 39 (06) : 644 - 656
  • [7] Role of tobacco in SARS-CoV-2 infection and COVID-19: A scoping review
    Banerjee, Bratati
    Banerjee, Rupsa
    INTERNATIONAL JOURNAL OF NONCOMMUNICABLE DISEASES, 2020, 5 (02) : 70 - 75
  • [8] SARS-CoV-2 Infection, Inflammation, Immunonutrition, and Pathogenesis of COVID-19
    Yu, Ligen
    Abd Ghani, Mohd Khanapi
    Aghemo, Alessio
    Barh, Debmalya
    Bassetti, Matteo
    Catena, Fausto
    Gallo, Gaetano
    Gholamrezanezhad, Ali
    Kamal, Mohammad Amjad
    Lal, Amos
    Sahu, Kamal Kant
    Saxena, Shailendra K.
    Elmore, Ugo
    Rahimi, Farid
    Robba, Chiara
    Song, Yuanlin
    Xia, Zhengyuan
    Yu, Boxuan
    CURRENT MEDICINAL CHEMISTRY, 2023, 30 (39) : 4390 - 4408
  • [9] SARS-CoV-2 infection and COVID-19 in Gaucher disease: indications for vaccination
    Laszlo, Marodi
    ORVOSI HETILAP, 2021, 162 (24) : 938 - 942
  • [10] Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease Running title: Propolis against SARS-CoV-2 infection and COVID-19
    Berretta, Andresa Aparecida
    Duarte Silveira, Marcelo Augusto
    Capcha, Jose Manuel Condor
    De Jong, David
    BIOMEDICINE & PHARMACOTHERAPY, 2020, 131
12345