Vocal Tremor: Novel Therapeutic Target for Deep Brain Stimulation

被引：8
作者：
Ravikumar, Vinod K. [1 ]
Ho, Allen L. [1 ]
Parker, Jonathon J. [1 ]
Erickson-DiRenzo, Elizabeth [1 ]
Halpern, Casey H. [1 ]
机构：
[1] Stanford Univ, Dept Neurosurg, 300 Pasteur Dr,Edwards Bldg R-293, Stanford, CA 94305 USA
来源：
BRAIN SCIENCES | 2016年 / 6卷 / 04期
关键词：
deep brain stimulation; awake DBS; ventral intermediate nucleus; VIM; dysphonia; essential tremor; essential vocal tremor; EVT; voice; tremulous voice; laryngoscopy; acoustic analysis; microelectrode recording; ACOUSTIC VOICE ANALYSIS; PRIMATE MOTOR THALAMUS; MOVEMENT-DISORDERS; PARKINSONS-DISEASE; SOMATOTOPIC ORGANIZATION; SUBTHALAMIC NUCLEUS; BOTULINUM TOXIN; DYT6; DYSTONIA; REDUCTION; MANAGEMENT;
D O I：
10.3390/brainsci6040048
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Tremulous voice is characteristically associated with essential tremor, and is referred to as essential vocal tremor (EVT). Current estimates suggest that up to 40% of individuals diagnosed with essential tremor also present with EVT, which is associated with an impaired quality of life. Traditional EVT treatments have demonstrated limited success in long-term management of symptoms. However, voice tremor has been noted to decrease in patients receiving deep brain stimulation (DBS) with the targeting of thalamic nuclei. In this study, we describe our multidisciplinary procedure for awake, frameless DBS with optimal stimulation targets as well as acoustic analysis and laryngoscopic assessment to quantify tremor reduction. Finally, we investigate the most recent clinical evidence regarding the procedure.
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页数：7
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